A histological study of experimental gingivitis in man.
A histological study of experimental gingivitis in man.
复制标题
人类实验性牙龈炎的组织学研究。
DOI：
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发表时间：
1968
影响因子：
3.5
通讯作者：
B. Zachrisson
中科院分区：
文献类型：
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作者：
B. Zachrisson
实验性牙龈炎诱导21人。在下颌前磨牙和磨牙区域，口腔卫生在口腔一侧的颊侧和邻间牙面上被废除。其他牙齿表面作为对照，并进行彻底的口腔卫生措施。15-17天后，当大多数受试者的非清洁侧出现临床上明显的牙龈炎时，从该侧以及对照侧获得活组织检查。实验侧组织的组织学检查显示炎性浸润主要局限于囊袋上皮相邻的结缔组织。细胞主要为中大型和小型淋巴细胞、巨噬细胞和成纤维细胞。在血管内、囊袋上皮附近和囊袋上皮内观察到少数嗜中性白细胞。未成熟和成熟的浆细胞被认为是在结缔组织的中心区域，但很少或缺乏接近袋上皮细胞的分布的不同类型的单核细胞可能是一致的淋巴细胞转化为浆细胞。
Experimental gingivitis was induced in 21 individuals. Oral hygiene was abolished on the buccal and interproximal tooth surfaces of one side of the mouth in the mandibular premolar and molar area. The other tooth surfaces served as controls and were subject to thorough oral hygiene measures. After 15–17 days, when clinically manifest gingivitis had developed in the non-cleansing side of the majority of the subjects, biopsies were obtained from that side as well as from the control side. Histological examination of tissue from the experimental side revealed inflammatory infiltrates largely confined to the connective tissue adjacent to the pocket epithelium. The cells were mainly medium-large and small lymphocytes, macrophages and fibroblasts. A few neutrophilic leukocytes were observed mostly inside the vessels and adjacent to and within the pocket epithelium. Immature and mature plasma cells were seen in the central regions of the connective tissue, but were scant or absent nearer to the pocket epithelium The distribution of the different types of mononuclear cells might be consistent with a transformation of lymphocytes into plasma cells.