Biocoordination chemistry of bismuth : Recent advances
Biocoordination chemistry of bismuth : Recent advances
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DOI：
10.1016/j.ccr.2007.03.003
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发表时间：
2007-09
影响因子：
20.6
通讯作者：
N. Yang;Hongzhe Sun
中科院分区：
文献类型：
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作者：
N. Yang;Hongzhe Sun
几个世纪以来，铋化合物在临床中被广泛使用，因为它们在治疗各种微生物感染方面高效低毒，包括梅毒、腹泻、胃炎和结肠炎。最近开发的以铋为基础的三联疗法在根除患者幽门螺杆菌方面的疗效超过了正常的以质子泵抑制剂为基础的ppi疗法。除了抗菌活性外，铋化合物还具有抗癌活性，212Bi和213bi化合物也被用作癌症治疗的靶向放射治疗剂，而且它们还具有减少顺铂在癌症治疗中的副作用的能力。研究铋与潜在的靶向生物分子，包括多肽、蛋白质和酶的相互作用，将有助于了解含铋复合物的作用机制，进而促进铋在医学上的进一步应用。
Bismuth compounds have been widely used in the clinic for centuries because of their high effectiveness and low toxicity in the treatment of a variety of microbial infections, including syphilis, diarrhea, gastritis and colitis. The efficacy of recently developed bismuth-based triple therapy in the eradication of Helicobacter pylori from patients exceeded the normal PPI-based (proton pump inhibitor-based) therapies. Apart from antimicrobial activity, bismuth compounds exhibit anticancer activities,212Bi and213Bi compounds have also been used as targeted radio-therapeutic agents for cancer treatment, and furthermore they have the ability to reduce the side-effects of cisplatin in cancer therapy. The investigation of bismuth interactions with potential targeting biomolecules, including peptides, proteins and enzymes will lead to an understanding of the mechanism of action of bismuth-containing complexes and in turn to the further application of bismuth in medicine.