Clinical and epidemiological characteristics of acute respiratory virus infections in Vietnamese children
Clinical and epidemiological characteristics of acute respiratory virus infections in Vietnamese children
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DOI：
10.1017/s095026881500134x
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发表时间：
2016-02-01
影响因子：
4.2
通讯作者：
Ushijima, H.
中科院分区：
文献类型：
--
作者：
Tran, D. N.;Trinh, Q. D.;Ushijima, H.
有关病毒性急性呼吸道感染 (ARIs) 的信息对于预防、诊断和治疗至关重要，但在热带发展中国家，这种信息有限。本研究描述了越南住院儿童急性呼吸道感染的临床和流行病学特征。 2010年4月至2011年5月期间，从胡志明市儿童医院2采集了急性呼吸道感染儿童的鼻咽样本，以便通过聚合酶链式反应检测呼吸道病毒。 1082 名患者中有 64% 发现了病毒，其中 12% 是合并感染。检测到的主要病毒是人鼻病毒（HRV；30%）、呼吸道合胞病毒（RSV；23.8%）和人博卡病毒（HBoV；7.2%）。 HRV全年均可检出，RSV流行主要发生在雨季。甲型流感（FluA）在两个季节都有发现。其他病毒在旱季占主导地位。 HRV 在所有年龄段的儿童中均得到检测。 RSV、副流感病毒 (PIV) 1、PIV3 和 HBoV 以及 FluA 分别主要在 24 个月大的儿童中检测到。 PIV1 与哮吼 (P < 0.005) 和 RSV 与细支气管炎 (P < 0.005) 之间存在显着相关性。 HBoV 和 HRV 与缺氧相关（P < 0.05），RSV 与回缩相关（P < 0.05）。 HRV、RSV 和 HBoV 检测最频繁，它们可能会增加儿童 ARI 的严重程度。
Information about viral acute respiratory infections (ARIs) is essential for prevention, diagnosis and treatment, but it is limited in tropical developing countries. This study described the clinical and epidemiological characteristics of ARIs in children hospitalized in Vietnam. Nasopharyngeal samples were collected from children with ARIs at Ho Chi Minh City Children's Hospital 2 between April 2010 and May 2011 in order to detect respiratory viruses by polymerase chain reaction. Viruses were found in 64% of 1082 patients, with 12% being co-infections. The leading detected viruses were human rhinovirus (HRV; 30%), respiratory syncytial virus (RSV; 23.8%), and human bocavirus (HBoV; 7.2%). HRV was detected all year round, while RSV epidemics occurred mainly in the rainy season. Influenza A (FluA) was found in both seasons. The other viruses were predominant in the dry season. HRV was identified in children of all age groups. RSV, parainfluenza virus (PIV) 1, PIV3 and HBoV, and FluA were detected predominantly in children aged 24 months, respectively. Significant associations were found between PIV1 with croup (P < 0.005) and RSV with bronchiolitis (P < 0.005). HBoV and HRV were associated with hypoxia (P < 0.05) and RSV with retraction (P < 0.05). HRV, RSV, and HBoV were detected most frequently and they may increase the severity of ARIs in children.