Methodological considerations when measuring and analyzing auditory steady-state responses with multi-channel EEG.
Methodological considerations when measuring and analyzing auditory steady-state responses with multi-channel EEG.
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DOI：
10.1016/j.crneur.2022.100061
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发表时间：
2022
期刊：
影响因子：
--
通讯作者：
Oxenham, Andrew J
中科院分区：
文献类型：
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作者：
Lu, Hao;Mehta, Anahita H;Oxenham, Andrew J
听觉稳态反应（ASSR）传统上是用少数几个电极记录的，通常用乳突和头顶电极之间的电压差（垂直蒙太奇）来测量。随着高密度脑电记录系统的普及，多通道分析方法被开发出来以整合跨通道的ASSR信号。跨电极ASSR的相位可以受到包括刺激调制速率和重参照策略在内的因素的影响，这反过来又会影响估计的ASSR强度。为了探讨经典的垂直蒙太奇ASSR和全头皮ASSR之间的关系，我们将这两种技术应用于相同的数据，以估计由正弦幅度调制率为40，100和200 Hz左右的音调诱发的ASSR的强度。在我们的研究中评估的全头皮方法，无论是链接乳突或共同平均参考，包括那些假设所有通道的相位相等，以及那些允许不同的相位关系。简单的平均性能进行了比较，更复杂的方法，包括主成分分析。总的来说，所有通道的锁相值（PLV）的均方根提供了在这里测试的调制速率范围内检测ASSR的最有效方法。听觉稳态反应（ASSR）测量频率特异性反应。ASSR预处理和量化技术进行了比较，使用人类数据。EEG参考值的选择影响ASSR的强度和相位。当测量ASSR时，乳突通道不是电中性的。全通道RMS相位锁定值是检测ASSR最有效的方法。
The auditory steady-state response (ASSR) has been traditionally recorded with few electrodes and is often measured as the voltage difference between mastoid and vertex electrodes (vertical montage). As high-density EEG recording systems have gained popularity, multi-channel analysis methods have been developed to integrate the ASSR signal across channels. The phases of ASSR across electrodes can be affected by factors including the stimulus modulation rate and re-referencing strategy, which will in turn affect the estimated ASSR strength. To explore the relationship between the classical vertical-montage ASSR and whole-scalp ASSR, we applied these two techniques to the same data to estimate the strength of ASSRs evoked by tones with sinusoidal amplitude modulation rates of around 40, 100, and 200 Hz. The whole-scalp methods evaluated in our study, with either linked-mastoid or common-average reference, included ones that assume equal phase across all channels, as well as ones that allow for different phase relationships. The performance of simple averaging was compared to that of more complex methods involving principal component analysis. Overall, the root-mean-square of the phase locking values (PLVs) across all channels provided the most efficient method to detect ASSR across the range of modulation rates tested here. The auditory steady-state response (ASSR) measures frequency-specific responses. ASSR pre-processing and quantification techniques were compared using human data. Choice of EEG reference affects measured strength and phase of ASSR. Mastoid channels are not electrically neutral when measuring ASSR. The all-channel RMS phase locking value is most efficient to detect ASSR.