Sex differences in the benefits of rehabilitative training during adolescence following neonatal hypoxia-ischemia in rats
Sex differences in the benefits of rehabilitative training during adolescence following neonatal hypoxia-ischemia in rats
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DOI：
10.1016/j.expneurol.2010.09.002
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发表时间：
2010-12-01
影响因子：
5.3
通讯作者：
Fujiwara, Michihiro
中科院分区：
文献类型：
--
作者：
Tsuji, Masahiro;Aoo, Naoya;Fujiwara, Michihiro
许多努力和许多资源都被投入到新生儿缺氧缺血性脑病造成的残疾儿童的康复计划中，但没有明确的证据表明这些计划的有效性。我们最近报道，在青春期的康复训练任务，改善空间学习障碍后，新生儿缺氧缺血性损伤的大鼠没有组织学改善。在本研究中，我们主要关注性别差异。Wister大鼠幼鼠在7日龄时暴露于单侧缺氧缺血性损伤。缺氧缺血6周后开始康复训练任务。任务包括十字迷宫、八臂迷宫和选择反应时任务。损伤后16周，采用水迷宫实验评价大鼠的空间学习能力。之后，我们对脑损伤进行了形态学检查。康复训练组女子游泳时间和游泳长度显著提高（P
Much effort and many resources are being devoted to rehabilitative programs for children with disabilities caused by neonatal hypoxic-ischemic encephalopathy without clear evidence of the efficacy of such programs. We recently reported that rehabilitative training tasks during adolescence improve spatial learning impairment following neonatal hypoxic-ischemic injury in rats without histological improvement. In the present study we focused on sex differences. Wister rat pups were exposed to a unilateral hypoxic-ischemic insult at 7 days of age. Six weeks after hypoxia-ischemia, rehabilitative training tasks were started. The tasks consisted of the plus maze, the eight-arm radial maze, and the choice reaction time task. Sixteen weeks after the insult, the water maze task was performed to evaluate spatial learning ability. Afterwards, we morphologically examined brain injury. Our rehabilitative training significantly improved swimming time and length in females (P