Photoelectric Protein Nanofibrils of α-Synuclein with Embedded Iron and Phthalocyanine Tetrasulfonate
Photoelectric Protein Nanofibrils of α-Synuclein with Embedded Iron and Phthalocyanine Tetrasulfonate
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DOI：
10.1002/anie.201006859
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发表时间：
2011-01-01
影响因子：
16.6
通讯作者：
Paik, Seung R.
中科院分区：
文献类型：
--
作者：
Choi, Yeon Sun;Kim, Jehoon;Paik, Seung R.
响应可见光的光电系统的发展在光捕获和光开关系统的制备方面得到了极大的关注，这将有助于传感器、电子学、光学信息处理系统和能量转换器件的构建。[1-3]卟啉分子因其优异的光子、电子和催化性能而被认为是理想的光致电子转移过程。[4-6]为了更有效和实用地利用这些性质，它们的分级超结构已经被设计成利用它们的自相互作用性质来控制独特的芳香化合物的空间排列。[7-9]在这里，我们展示了在铁的存在下，卟啉化合物四磺酸盐(PCTS)选择性地定位于由α-突触核蛋白组成的淀粉样纤维的蛋白质基质中，这导致了介电蛋白质纳米纤维转化为光诱导的导电杂化纳米材料。
The development of photoelectric systems that respond to visible light has gained a great deal of attention for the preparation of light-harvesting and optical-switching systems, which would contribute to the construction of sensors, electronics, optical information processing systems, and energy-transducing devices.[1–3] Porphyrinic molecules are considered to be ideal for the photoinduced electron-transfer process owing to their excellent photonic, electronic, and catalytic properties.[4–6] To harness these properties in a more effective and practical way, their hierarchical suprastructures have been engineered to give rise to controlled spatial arrangement of the unique aromatic compounds by taking advantage of their self-interactive property.[7–9] Herein, we demonstrate selective localization of the porphyrinic compound phthalocyanine tetrasulfonate (PcTS) into a protein matrix of amyloid fibrils made of α-synuclein in the presence of iron, which results in conversion of the dielectric protein nanofibrils into light-inducible conductive hybrid nanomaterials.