Seroprevalence of avian influenza A (H5N1) virus among poultry workers in Jiangsu Province, China: an observational study
Seroprevalence of avian influenza A (H5N1) virus among poultry workers in Jiangsu Province, China: an observational study
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DOI：
10.1186/1471-2334-12-93
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发表时间：
2012-04-18
影响因子：
3.7
通讯作者：
Zhu, Fengcai
中科院分区：
文献类型：
--
作者：
Huo, Xiang;Zu, Rongqiang;Zhu, Fengcai
背景：2003年至2012年1月6日，中国实验室确诊人感染禽流感病例41例，死亡27例。然而，官方对H5N1病死率的估计被一些人描述为高估，因为可能有许多未发现的无症状/轻度H5N1感染病例。为更好地了解H5N1病毒人兽共患传播的真实感染率，评估H5N1病毒人畜共患传播的潜在危险因素。方法：对江苏省3个野禽栖息地湖泊的养禽业从业人员进行血清流行病学调查，调查对象为禽类接触水平最高的人群中国。从306名参与者中采集血清样本进行H5N1血清学检测。结果：H5N1抗体总阳性率为2.61%。经年龄和性别调整后，家禽数量与亚临床感染风险显着增加2.39倍相关。结论：H5N1禽流感病毒在禽类与人之间的传播仍然较低。与饲养较大家禽群相关的工人有更高的血清转换风险。
Background: Since 2003 to 06 Jan 2012, the number of laboratory confirmed human cases of infection with avian influenza in China was 41 and 27 were fatal. However, the official estimate of the H5N1 case-fatality rate has been described by some as an over estimation since there may be numerous undetected asymptomatic/mild cases of H5N1 infection. This study was conducted to better understand the real infection rate and evaluate the potential risk factors for the zoonotic spread of H5N1 viruses to humans.Methods: A seroepidemiological survey was conducted in poultry workers, a group expected to have the highest level of exposure to H5N1-infected birds, from 3 counties with habitat lakes of wildfowl in Jiangsu province, China. Serum specimens were collected from 306 participants for H5N1 serological test. All participants were interviewed to collect information about poultry exposures.Results: The overall seropositive rate was 2.61% for H5N1 antibodies. The poultry number was found associated with a 2.39-fold significantly increased subclinical infection risk after adjusted with age and gender.Conclusions: Avian-to -human transmission of avian H5N1 virus remained low. Workers associated with raising larger poultry flocks have a higher risk on seroconversion.