The impact of sex on brain responses to smoking cues: a perfusion fMRI study.
The impact of sex on brain responses to smoking cues: a perfusion fMRI study.
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DOI：
10.1186/2042-6410-4-9
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发表时间：
2013-04-29
影响因子：
7.9
通讯作者：
Franklin TR
中科院分区：
文献类型：
--
作者：
Wetherill RR;Young KA;Jagannathan K;Shin J;O'Brien CP;Childress AR;Franklin TR
轶事和临床理论声称女性对吸烟线索更敏感，但很少对这些理论进行客观的神经生理学检查。目前的研究探讨了性对大脑对吸烟线索反应的影响。五十一名（31 名男性）依赖香烟的吸烟者在暴露于视觉吸烟线索和非吸烟线索期间接受了伪连续动脉自旋标记灌注功能磁共振成像。分别检查男性和女性对吸烟线索相对于不吸烟线索的大脑反应，然后在男性和女性之间进行比较。每天吸的香烟作为协变量纳入分析中。与不吸烟线索相比，男性和女性对吸烟线索的反应均增加，其中男性表现出内侧眶额皮质和腹侧纹状体/腹侧苍白球反应增加，而女性表现出内侧眶额皮质反应增加。男性和女性大脑反应之间的直接比较表明，相对于非吸烟线索，男性对吸烟线索表现出更大的双侧海马/杏仁核激活。在先验奖励相关区域中，相对于非吸烟线索，男性和女性对吸烟线索表现出相似的反应；然而，性别之间的直接比较表明，吸烟暗示会引起男性双侧海马/杏仁核的更大激活。鉴于目前关于吸烟线索神经活动性别差异的文献很少且不完整，这些结果有助于我们了解药物线索反应性的神经生物学基础。
Anecdotal and clinical theories purport that females are more responsive to smoking cues, yet few objective, neurophysiological examinations of these theories have been conducted. The current study examines the impact of sex on brain responses to smoking cues. Fifty-one (31 males) cigarette-dependent sated smokers underwent pseudo-continuous arterial spin-labeled perfusion functional magnetic resonance imaging during exposure to visual smoking cues and non-smoking cues. Brain responses to smoking cues relative to non-smoking cues were examined within males and females separately and then compared between males and females. Cigarettes smoked per day was included in analyses as a covariate. Both males and females showed increased responses to smoking cues compared to non-smoking cues with males exhibiting increased medial orbitofrontal cortex and ventral striatum/ventral pallidum responses, and females showing increased medial orbitofrontal cortex responses. Direct comparisons between male and female brain responses revealed that males showed greater bilateral hippocampal/amygdala activation to smoking cues relative to non-smoking cues. Males and females exhibit similar responses to smoking cues relative to non-smoking cues in a priori reward-related regions; however, direct comparisons between sexes indicate that smoking cues evoke greater bilateral hippocampal/amygdalar activation among males. Given the current literature on sex differences in smoking cue neural activity is sparse and incomplete, these results contribute to our knowledge of the neurobiological underpinnings of drug cue reactivity.