Expression of hypoxia-inducible factor-1 alpha and its prognostic significance in small-sized adenocarcinomas of the lung
Expression of hypoxia-inducible factor-1 alpha and its prognostic significance in small-sized adenocarcinomas of the lung
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DOI：
10.1016/j.ejcts.2006.03.027
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发表时间：
2006-06-01
影响因子：
3.4
通讯作者：
Kuroki, Masahide
中科院分区：
文献类型：
--
作者：
Enatsu, Sotarou;Iwasaki, Akinori;Kuroki, Masahide
目的：分析低氧诱导因子-1α(HIF-1α)在肺小腺癌中的表达及其与临床病理参数和血管内皮生长因子-A、C表达的关系。方法：采用免疫组织化学方法检测78例小体腺癌(最大径)中缺氧诱导因子-1α的表达。
Objective: To analyze the prognostic value of hypoxia-inducible factor-1 (HIF-1) alpha expression and its correlation with clinicopathologic variables and the expression of vascular endothelial growth factor-A and -C in patients with lung adenocarcinomas of small size. Methods: The expression of hypoxia-inducible factor-1 alpha was immunohistochemically determined in 78 cases of small-sized adenocarcinoma (maximum dimension