Understanding the Role of the Death Receptor 5/FADD/caspase-8 Death Signaling in Cancer Metastasis.
Understanding the Role of the Death Receptor 5/FADD/caspase-8 Death Signaling in Cancer Metastasis.
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发表时间：
2011
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通讯作者：
Shi-Yong Sun
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作者：
Shi-Yong Sun
外源性凋亡途径的正常功能是介导凋亡。因此，该途径通常被认为在针对癌症的宿主免疫监视中是关键的。然而，许多研究表明，该通路中的一些关键组分包括Fas、死亡受体5（DR 5）、Fas相关死亡结构域（FADD）和caspase-8可能有助于癌症的生长或转移。我们最近对人头颈癌组织中DR 5和caspase-8表达的研究表明，在淋巴结转移患者的肿瘤组织中，高水平的caspase-8单独或沿着高水平的DR 5与低的无病生存率和总生存率显著相关，提示这些蛋白可能参与了癌症转移的正性调节。因此，应该努力更好地理解死亡受体5/FADD/caspase-8死亡信号传导在调节癌症转移中的作用。
The normal function of the extrinsic apoptotic pathway is to mediate apoptosis. Thus, this pathway is generally recognized to be critical in host immune surveillance against cancer. However, many studies have suggested that some key components in this pathway including Fas, death receptor 5 (DR5), Fas-associated death domain (FADD) and caspase-8 may contribute to cancer growth or metastasis. Our recent study on DR5 and caspase-8 expression in human head and neck cancer tissues indicate that high caspase-8 either alone or along with high DR5 in tumor tissue from patients with lymph node metastasis is significantly associated with poor disease-free survival and overall survival, suggesting that these proteins may be involved in positive regulation of cancer metastasis. Thus, efforts should be made to better understand the role of the death receptor 5/FADD/caspase-8 death signaling in regulation of cancer metastasis.