PHYSIOLOGICAL STUDIES OF RECIPROCAL CONNECTIONS BETWEEN HIPPOCAMPUS AND ENTORHINAL CORTEX
PHYSIOLOGICAL STUDIES OF RECIPROCAL CONNECTIONS BETWEEN HIPPOCAMPUS AND ENTORHINAL CORTEX
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DOI：
10.1016/0014-4886(75)90194-6
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发表时间：
1975-01-01
影响因子：
5.3
通讯作者：
LYNCH, G
中科院分区：
文献类型：
--
作者：
DEADWYLER, SA;WEST, JR;LYNCH, G
神经生理学记录从[大鼠]海马，内嗅皮层和齿状回的条件下，控制电刺激在互连的途径，以确认其双向性所建议的最近的解剖学研究结果。海马到内嗅通路的存在在生理学上通过诱发场电位的存在和刺激同侧和对侧海马的CA3子场后内嗅皮层的单一驱动来证实。通过这些程序激活内嗅皮层，导致随后通过穿通通路的轴突投射激发齿状回的颗粒细胞。研究结果进行了讨论的背景下，已知的解剖电路，这可能提供这种双向相互作用的基础。内嗅皮层以一致的方式响应海马激活并将该信息传回齿状回，从而完成边缘系统电路3个主要组成部分之间的重要3链回路，这一事实表明了所证明的生理连接的功能意义。
Neurophysiological recordings were obtained from the [rat] hippocampus, entorhinal cortex and dentate gyrus under conditions of controlled electrostimulation at interconnecting pathways to confirm their bidirectional nature as suggested by recent anatomical findings. The existence of a hippocampal to entorhinal pathway was confirmed physiologically by the presence of evoked field potentials and unitary driving of the entorhinal cortex following stimulation of the CA3 subfields of the ipsilateral and contralateral hippocampus. Activation of the entorhinal cortex by such procedures led to a subsequent excitation of the granule cells of the dentate gyrus through the axonal projections of the perforant pathway. The findings are discussed in the context of known anatomical circuitry which might provide the basis for such bidirectional interactions. The functional significance of the demonstrated physiological connections was indicated by the fact that the entorhinal cortex responds to hippocampal activation in a consistent manner and transmits that information back to the dentate gyrus, thereby completing an important 3 chain loop between 3 major components of limbic system circuitry.