THE EFFECT OF IODIDE INGESTION ON THE DEVELOPMENT OF SPONTANEOUS LYMPHOCYTIC THYROIDITIS IN THE DIABETES-PRONE BB/W RAT
THE EFFECT OF IODIDE INGESTION ON THE DEVELOPMENT OF SPONTANEOUS LYMPHOCYTIC THYROIDITIS IN THE DIABETES-PRONE BB/W RAT
复制标题
DOI：
10.1210/endo-118-5-1977
复制
发表时间：
1986-05-01
期刊：
影响因子：
4.8
通讯作者：
BRAVERMAN, LE
中科院分区：
文献类型：
--
作者：
ALLEN, EM;APPEL, MC;BRAVERMAN, LE
有人认为，高碘摄入会增加桥本甲状腺炎的发病率。糖尿病易感BB/W大鼠在60 - 120日龄之间发生自发性组织学自身免疫性淋巴细胞性甲状腺炎（LT），无功能性甲状腺功能减退。进行研究以确定BB/W大鼠的碘化物给药是否会影响LT的发生率和严重程度并诱导甲状腺功能减退。对42只10月龄BB/W大鼠和71只30日龄BB/W大鼠随意给予碘化物（0.05%水溶液）或自来水（C），持续8周。为了对照目的，还向42只30日龄非糖尿病和非LT倾向BB/W遗传等效大鼠（W系）随意给予0.05%碘化物或自来水（C）12周，并向41只21日龄Wistar大鼠随意给予7周。在一项单独的实验中，断奶BB/W大鼠随意喂食低碘饲料、对照碘充足（C）饲料或Purina食物（P）和自来水8周。在每项实验中，在死亡时采集血液，用于测量血清T4、T3、TSH和抗甲状腺球蛋白抗体（抗Tg Ab），并取出甲状腺进行组织学评价（0 =无LT; 1-4 = LT）。在30日龄BB/W大鼠中，碘剂给药（0.05%）诱导LT发生率显著增加（I，77%; C，30%，P <0.001）。甲状腺重量和血清T4，T3和抗Tg抗体浓度不受碘化物管理。然而，LT的存在与甲状腺重量和抗Tg Ab浓度的显著增加相关。BB/W大鼠低碘饮食组LT发生率明显降低（低碘组8.6%; C组47.3%; P < 0.01），但抗Tg抗体水平无显著性差异。增加碘摄入量并没有显着影响LT的发病率在成年BB/W大鼠，并没有诱导LT或影响甲状腺功能在W系或Wistar大鼠。这些数据表明，碘摄入量显着影响自发LT的年轻，遗传易感大鼠的发病率。
It has been suggested that the incidence of Hashimoto''s thyroiditis is increased in the presence of high iodide intake. The diabetes-prone BB/W rat develops spontaneous histological autoimmune lymphocytic thyroiditis (LT) without functional hypothyroidism between 60 and 120 days of age. Studies were carried out to determine whether iodide administration of BB/W rats would affect the incidence and severity of LT and induce hypothroidism. Iodide (0.05% in water) or tap water (C) was administered ad libitum to 42 10-month-old BB/W rats and 71 30-day-old BB/W rats for 8 weeks. For control purpose, 0.05% iodide or tap water (C) was also administered ad libitum to 42 30-day-old nondiabetic and non-LT-prone BB/W genetically equivalent rats (W-line) for 12 weeks and 41 21-day-old Wistar rats for 7 weeks. In a separate experiment, weanling BB/W rats were fed a low iodine diet, a control iodine-sufficient (C) diet, or Purina chow (P) and tap water ad libitum for 8 weeks. In each experiment, blood was obtained at the time of death for the measurement of serum T4, T3, TSH, and antithyroglobulin antibody (anti-Tg Ab), and the thryoids were removed for histoloigical evaluation (0 = no LT; 1-4 = LT). Iodide adminstration (0.05%) induced a significant increase in the incidence of LT in 30-day-old BB/W rats (I, 77%; C, 30%, P < .001). Thyroid weight and serum T4, T3, and anti-Tg Ab concentrations were not affected by iodide administration. However, the presence of LT was associated with a significant increase in thyroid weight and anti-Tg Ab concentrations. BB/W rats subjected to a low iodine diet exhibited a significantly decreased incidence of LT (low I, 8.6%; C, 47.3%; P < 0.01), but no statistically significant difference in anti-Tg Ab levels. Increased iodide intake did not significantly affect the incidence of LT in adult BB/W rats and did not induce LT or affect thyroid function in W-line or Wistar rats. These data show that iodine intake significantly affects the incidence of spontaneous LT in young, genetically predisposed rats.