Leptin treatment during the neonatal period is associated with higher food intake and adult body weight in rats
Leptin treatment during the neonatal period is associated with higher food intake and adult body weight in rats
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DOI：
10.1055/s-2002-33473
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发表时间：
2002-07-01
影响因子：
2.2
通讯作者：
Ramos, C
中科院分区：
文献类型：
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作者：
Cravo, CD;Teixeira, CV;Ramos, C
在这项研究中，我们确定了新生儿瘦素治疗对体重演变的影响。实验一：幼崽被分为两组：LepF -在哺乳期的前10天注射瘦素（8 μ g/100 g体重），对照组（C）-接受盐水。实验二：将幼仔分成两组：LepL -在哺乳期的最后10天注射与实验1相同的瘦素浓度，C组接受盐水。体重和食物摄入量进行了监测，直到年龄150天，之后瘦素浓度测定ELISA。与对照组相比，LepF组从第98天开始体重显著增加（p <0.05），从第74天开始食物摄入显著增加（p < 0.05），血清瘦素浓度更高（108%，p < 0.05）。与对照组相比，LepL组从第113天开始体重显著增加（p < 0.05），从第121天开始食物摄入显著增加（p < 0.001），血清瘦素浓度更高（6.9%，p < 0.05）。这些结果表明，这两个时期的哺乳期构成了一个关键的窗口体重和食物摄入规划，但效果更显着时，瘦素注射在前10天。
For this study, we have determined the effects of neonatal leptin treatment on the evolution of body weight. Experiment 1: pups were divided into two groups: LepF - injected with leptin (8 mug/100 g of body weight) for the first 10 days of lactation and control (C) - receiving saline. Experiment 2: pups were divided into two groups: LepL - injected with the same leptin concentration of experiment one for the last 10 days of lactation, and C, which received saline. Body weight and food intake were monitored until age 150 days, after which leptin concentrations were measured by ELISA. The LepF group had a significant increase in body weight (p < 0.05) from day 98 onward, in food intake (p < 0.05) from day 74 onward, and higher serum leptin concentration compared to the control (108 %, p < 0.05). The LepL group had a significant increase in body weight (p < 0.05) from day 113 onward, in food intake from day 121 onward (p < 0.001), and higher serum leptin concentration compared to controls (6.9%, p < 0.05). These results suggest that both periods of lactation constituted a critical window for body weight and food intake programming, but the effects are more marked when the leptin is injected within the first ten days.