Re: Genome-Wide Plasma DNA Methylation Features of Metastatic Prostate Cancer.
Re: Genome-Wide Plasma DNA Methylation Features of Metastatic Prostate Cancer.
复制标题
回复：转移性前列腺癌的全基因组血浆 DNA 甲基化特征。
DOI：
10.1097/ju.0000000000001263.01
复制
发表时间：
2020
期刊：
影响因子：
--
通讯作者：
Atala A
中科院分区：
文献类型：
--
作者：
Atala A
编辑评论：作者鉴定了FOXA 1顺式调节元件，这些元件被单核苷酸变体靶向，能够通过调节关键的前列腺癌转录因子来改变反式激活潜力。这项研究支持了将顺式调控元件不仅视为单独出现的重要性，而且作为一个团队共同努力调节靶基因，特别是在考虑遗传改变的影响时。因此，该研究在理解FOXA 1转录调控和FOXA 1抑制的新途径之间架起了一座桥梁。这些发现支持了FOXA 1在前列腺癌中的致癌本质。深入了解前列腺癌中重要基因（如FOXA 1）的顺式调控丛，可能为抑制各种癌症类型的其他驱动因素以阻止疾病进展提供新的途径。
Editorial Comment: The authors identified FOXA1 cis-regulatory elements targeted by single nucleotide variants that are capable of altering transactivation potential through the modulation of key prostate cancer transcription factors. The study supports the importance of considering cis-regulatory elements not only as lone occurrences, but as a team working together to regulate the target genes, particularly when considering the impact of genetic alterations. As such, the study builds a bridge between the understanding of FOXA1 transcriptional regulation and new routes to FOXA1 inhibition. The findings support the oncogenic nature of FOXA1 in prostate cancer. Gaining insight into the cis-regulatory plexuses of important genes such as FOXA1 in prostate cancer may provide new avenues to inhibit other drivers across various cancer types to halt disease progression.