Long term follow-up on quality of life and its relationship to motor and cognitive functions in Parkinson's disease after deep brain stimulation
Long term follow-up on quality of life and its relationship to motor and cognitive functions in Parkinson's disease after deep brain stimulation
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DOI：
10.1016/j.jns.2017.05.037
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发表时间：
2017-08-15
影响因子：
4.4
通讯作者：
Kuwabara, Satoshi
中科院分区：
文献类型：
--
作者：
Yamamoto, Tatsuya;Uchiyama, Tomoyuki;Kuwabara, Satoshi
简介：我们旨在研究帕金森病（PD）患者在丘脑下核深部脑刺激（STN-DBS）后健康相关生活质量（HRQOL）的时间变化及其与运动和认知功能的关系。方法：共纳入31例PD患者，平均年龄66.7 +/- 0.9岁，平均病程11.6 +/- 3.7年。参与者完成了统一帕金森病评定量表和帕金森病问卷-39。认知功能评估采用迷你精神状态检查，正面评估电池，和蒙特利尔认知评估。术后评估分别于术后3个月、1年、3年和5年进行；在所有随访期间评估HRQOL与运动和认知功能之间相关性的时间变化。结果：所有患者均于术后3个月、1年后完成临床评估。在31名参与者中，12人在3年后完成了术后临床评估，7人在5年后完成了术后临床评估。运动功能在5年随访期间有显著改善。HRQOL的活动度子域恶化，而总分多年来没有明显变化。在随访期间，认知功能没有明显受损。随访期间HRQOL与运动和认知功能基本无显著相关。结论：PD患者STN-DBS术后HRQOL活动亚域恶化，运动功能改善与HRQOL基本无相关性。在随访期间，认知功能没有明显受损。(C) 2017年Elsevier B.V.出版
Introduction: We aimed to examine temporal changes in health-related quality of life (HRQOL) and its relationship with motor and cognitive functions in patients with Parkinson's disease (PD) after subthalamic nucleus deep brain stimulation (STN-DBS).Methods: In total, 31 patients with PD were enrolled in this study (mean age: 66.7 +/- 0.9 years; mean disease duration: 11.6 +/- 3.7 years). Participants completed the Unified Parkinson's Disease Rating Scale and the Parkinson's Disease Questionnaire-39. Cognitive function was assessed using the Mini Mental State Examination, the Frontal Assessment Battery, and the Montreal Cognitive Assessment. Postoperative evaluation was performed at three months, one year, three years, and five years after surgery; temporal changes in the correlation between HRQOL and motor and cognitive functions were evaluated at all follow-up periods.Results: All patients completed postoperative clinical evaluations after three months, after one year. Of the 31 participants, twelve completed postoperative clinical evaluations after three years and seven after five years. Motor functions showed significant improvement over the five-year follow-up period. The mobility subdomain of the HRQOL worsened whereas the total score did not change significantly over years. Cognitive functions were not significantly impaired during follow-up periods. HRQOL was basically not significantly correlated with motor and cognitive functions during the follow-up period.Conclusions: The mobility subdomain of the HRQOL worsened after surgery, and the improvement in motor functions was basically not correlated with HRQOL after STN-DBS in patients with PD. Cognitive functions were not significantly impaired during follow-up periods. (C) 2017 Published by Elsevier B.V.