Helicobacter pylori gastritis in cats with long-term natural infection as a model of human disease
Helicobacter pylori gastritis in cats with long-term natural infection as a model of human disease
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DOI：
10.1016/s0002-9440(10)64774-8
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发表时间：
2000-02-01
影响因子：
6
通讯作者：
Fox, JG
中科院分区：
文献类型：
--
作者：
Esteves, MI;Schrenzel, MD;Fox, JG
在一个封闭的动物群体中，2岁以下的家猫（Felis catus）自然感染幽门螺杆菌（H. pylori），对该群体中的6只猫进行了为期3年的培养、聚合酶链反应、光镜和电子显微镜的连续评估，结果显示幽门螺杆菌的单一cag(-) vac（+）菌株在胃中持续定植。在这些猫以及其他5- 6岁的猫中，长期感染导致慢性弥漫性淋巴滤泡性萎缩性胃炎，胃窦粘膜发育不良，主要是身体和心脏的中浅表胃炎。从地形上看，幼猫和老年猫的病变分布相似，与人类非常相似，最严重的变化发生在胃窦。与未感染的对照组相比，老年幽门螺杆菌感染猫的粒细胞较少，肥大细胞无显著升高；然而，与未感染的对照组和年轻猫相比，老年感染猫的胃炎指数显著高于未感染的对照组（P < 0.05）。感染老年猫胃窦细胞增殖指数显著（P = 0.021）高于未感染对照组，胃窦和体细胞凋亡指数显著（P = 0.01）高于未感染对照组。猫的慢性幽门螺杆菌感染与人类的长期幽门螺杆菌感染有许多相同的特征，包括肿瘤前病变的发展。这种相似性为宿主-病原体相互作用提供了有用的、比较的见解。
A natural infection with Helicobacter pylori (H. pylori) in domestic cats (Felis cattus) less than 2 years of age has been well described in a closed colony of animals, Six cats from this colony that were serially evaluated by culture, polymerase chain reaction, and light and electron microscopy for a period of 3 years demonstrated persistent gastric colonization with a single cag(-) vac(+) strain of H, pylori. In these cats, as well as five other 5- to 6-year-old cats that were examined, a long-term infection resulted in chronic diffuse lymphofollicular atrophic gastritis with areas of mucosal dysplasia in the antrum and predominantly midsuperficial gastritis in the body and cardia, Topographically, the distribution of lesions was similar in both young and older cats and closely resembled that found in humans, with the most severe changes occurring in the gastric antrum. Few granulocytes and no significant elevation in mast cells were seen in older H, pylori-infected cats compared with uninfected controls; however, marked increases in interepithelial globule leukocytes and numerous active mucosal lymphoid follicles were present in infected animals, Indices of gastritis were significantly greater in older infected cats when compared with uninfected controls and younger cats (P < 0.05). The antral cell proliferation index of infected older cats was significantly (P = 0.021) greater than that of uninfected controls, Apoptotic indices of the gastric antrum and body of infected cats were significantly (P = 0.01) increased versus controls. Chronic infection with H, pylori in cats shares many features of long-term H, pylori infection in humans, including the development of preneoplastic processes. This similarity provides useful, comparative insights into host-pathogen interactions.