Effectiveness of HPV vaccination against high grade cervical lesions in Japan
Effectiveness of HPV vaccination against high grade cervical lesions in Japan
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DOI：
10.1016/j.vaccine.2018.05.048
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发表时间：
2018-12-18
期刊：
影响因子：
5.5
通讯作者：
Kakizoe, Tadao
中科院分区：
文献类型：
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作者：
Konno, Ryo;Konishi, Hiroshi;Kakizoe, Tadao
日本第一个队列中针对 HSIL+（病理诊断为 CIN2+）的 HPV 疫苗的有效性在 22,743 名 20 至 29 岁女性中进行了调查（日本癌症协会 2015 财年国家宫颈癌筛查计划的一部分）。与未接种疫苗的女性相比，接种疫苗的女性患 HSIL+ 的风险显着降低 69%；根据正态近似，粗相对风险估计值为 0.31（95% CI：0.11-0.83；p 值 = 0.013）；根据精确泊松回归，粗相对风险估计值为 0.31（95% CI：0.08-0.80；p 值 = 0.009）。年龄的影响并不显着（chisq = 7.7 (df = 9)，p 值 = 0.569），并且在调整年龄后相对风险的估计基本保持不变。这项研究为 HPV 疫苗对宫颈高度病变发展的有效性提供了科学证据。 (C) 2018 作者。由爱思唯尔有限公司出版
The effectiveness of HPV vaccine against HSIL+ (pathologically diagnosed CIN2+) in the first cohort in Japan was investigated in 22,743 women aged 20 to 29 years (parts of national cervical cancer screening program of FY [fiscal year] 2015, the Japan Cancer Society). Vaccinated women had a statistically significant 69% lower risk of HSIL+ as compared to the unvaccinated women; the crude relative risk estimate was 0.31 (95% CI: 0.11-0.83; p-value = 0.013) by normal approximation and 0.31 (95% Cl: 0.08-0.80; p-value = 0.009) by the exact Poisson regression. The effect of age was not significant (chisq = 7.7 (df = 9), p-value = 0.569) and the estimate of relative risk remained essentially intact after adjustment for age. This study brings scientific evidence on the effectiveness of HPV vaccine on development of cervical high grade lesions. (C) 2018 The Authors. Published by Elsevier Ltd.