qHTSWaterfall: 3-dimensional visualization software for quantitative high-throughput screening (qHTS) data.
qHTSWaterfall: 3-dimensional visualization software for quantitative high-throughput screening (qHTS) data.
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QHTSWaterfall：用于定量高通量筛选(QHTS)数据的三维可视化软件。
DOI：
10.1186/s13321-023-00717-9
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发表时间：
2023-03-31
影响因子：
8.6
通讯作者：
中科院分区：
文献类型：
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作者：
High throughput screening (HTS) is widely used in drug discovery and chemical biology to identify and characterize agents having pharmacologic properties often by evaluation of large chemical libraries. Standard HTS data can be simply plotted as an x–y graph usually represented as % activity of a compound tested at a single concentration vs compound ID, whereas quantitative HTS (qHTS) data incorporates a third axis represented by concentration. By virtue of the additional data points arising from the compound titration and the incorporation of logistic fit parameters that define the concentration–response curve, such as EC50 and Hill slope, qHTS data has been challenging to display on a single graph. Here we provide a flexible solution to the rapid plotting of complete qHTS data sets to produce a 3-axis plot we call qHTS Waterfall Plots. The software described here can be generally applied to any 3-axis dataset and is available as both an R package and an R shiny application. The online version contains supplementary material available at 10.1186/s13321-023-00717-9.
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影响因子：
13.8
作者：
Kim, Myung Sun;Prasad, Vinay
通讯作者：
Prasad, Vinay
DOI：
10.2174/1875397301004010057
发表时间：
2010-10-21
期刊：
Current chemical genomics
影响因子：
--
作者：
Wang Y;Jadhav A;Southal N;Huang R;Nguyen DT
通讯作者：
Nguyen DT
影响因子：
3.7
作者：
Dranchak P;MacArthur R;Guha R;Zuercher WJ;Drewry DH;Auld DS;Inglese J
通讯作者：
Inglese J
影响因子：
8.6
作者：
Fu G;Batchelor C;Dumontier M;Hastings J;Willighagen E;Bolton E
通讯作者：
Bolton E
影响因子：
14.9
作者：
Kim S;Thiessen PA;Bolton EE;Chen J;Fu G;Gindulyte A;Han L;He J;He S;Shoemaker BA;Wang J;Yu B;Zhang J;Bryant SH
通讯作者：
Bryant SH