True and phantom recollection: An fMRI investigation of similar and distinct neural correlates and connectivity
True and phantom recollection: An fMRI investigation of similar and distinct neural correlates and connectivity
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DOI：
10.1016/j.neuroimage.2011.09.079
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发表时间：
2012-02-01
期刊：
影响因子：
5.7
通讯作者：
Vandekar, Simon N.
中科院分区：
文献类型：
--
作者：
Dennis, Nancy A.;Bowman, Caitlin R.;Vandekar, Simon N.
尽管研究表明大多数错误记忆是由熟悉感介导的，但行为证据表明，有些错误记忆的特点是检索与回忆相关的特定项目细节。然而，神经影像学研究尚未分离和分析错误（或幻影）记忆的神经相关性，而是关注一般的识别过程。在此过程中，关于内侧颞叶 (MTL) 在区分真假检索中的作用，结果是混合的。本研究旨在研究真实记忆和幻影记忆的神经基础，并阐明 MTL 在分离这两个过程中的作用。结果表明，真实记忆和幻象记忆与很大程度上重叠的检索网络相关，包括双侧前海马旁回、梭状回、前扣带皮层和右顶叶上皮层的活动。然而，使用两个常见 MTL 种子的连通性分析揭示了与真实回忆相关的更下级网络（梭状回、海马、颞中回）和与错误回忆相关的更高级网络（顶上、额上回、后扣带皮层）。最后，真实记忆和幻象记忆之间的直接比较显示，右侧海马体和早期视觉皮层的真实记忆活动更大，而没有任何区域表现出更大的错误记忆活动。结果表明，虽然真实记忆和幻象记忆都显示出相似的激活模式，但促进这两种记忆过程的神经网络也存在差异。此外，结果表明，在 MTL 内，海马体本身可以区分真实记忆和幻影记忆。 (C) 2011 Elsevier Inc. 保留所有权利。
Although research suggests that most false memories are mediated by a sense of familiarity, behavioral evidence indicates that some are characterized by retrieval of item-specific details associated with recollection. However, neuroimaging studies have yet to isolate and analyze the neural correlates of false (or phantom) recollection, focusing instead on general recognition processes. In doing so, results are mixed with respect to the role of the medial temporal lobes (MTL) in distinguishing between true and false retrieval. The present study sought to investigate the neural basis of true and phantom recollection and clarify the role of the MTL in dissociating between the two processes. Results showed that true and phantom recollection were associated with a largely overlapping retrieval network including activity in bilateral anterior parahippocampal gyrus, fusiform gyrus, anterior cingulate cortex, and right superior parietal cortex. However, connectivity analyses using two common MTL seeds revealed a more inferior network (fusiform gyrus, hippocampus, middle temporal gyrus) associated with true recollection and a more superior network (superior parietal, superior frontal gyrus, posterior cingulate cortex) associated with false recollection. Finally, direct comparisons between true and phantom recollection showed greater activity in right hippocampus and early visual cortex for true recollection, whereas no region exhibited greater activity for false recollection. Results indicate that while both true and phantom recollection show similar patterns of activation, there are also distinctions in the neural networks contributing to the two recollection processes. Moreover, results conclude that within the MTL, the hippocampus proper can distinguish between true and phantom recollection. (C) 2011 Elsevier Inc. All rights reserved.