Does M. tuberculosis genomic diversity explain disease diversity?
Does M. tuberculosis genomic diversity explain disease diversity?
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DOI：
10.1016/j.ddmec.2010.09.004
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
Gagneux, Sebastien
中科院分区：
文献类型：
--
作者：
Coscolla, Mireilla;Gagneux, Sebastien
结核病感染和疾病的结果是高度可变的。这种变异主要归因于宿主和环境因素，但更好地了解全球基因组多样性的M。结核复合征（MTBC）表明细菌因素也可能参与其中。对近100份已发表报告的回顾表明，MTBC菌株在实验模型中的毒力和免疫原性不同，但这种表型变异是否在人类疾病中发挥作用仍不清楚。考虑到宿主、病原体和环境之间复杂的相互作用，将MTBC基因型多样性与实验和临床表型联系起来需要一种嵌入强大进化框架的综合系统流行病学方法。
The outcome of tuberculosis infection and disease is highly variable. This variation has been attributed primarily to host and environmental factors, but better understanding of the global genomic diversity in the M. tuberculosis complex (MTBC) suggests that bacterial factors could also be involved. Review of nearly 100 published reports shows that MTBC strains differ in their virulence and immunogenicity in experimental models, but whether this phenotypic variation plays a role in human disease remains unclear. Given the complex interactions between the host, the pathogen and the environment, linking MTBC genotypic diversity to experimental and clinical phenotypes requires an integrated systems epidemiology approach embedded in a robust evolutionary framework.