Magnetite Nanoparticles for Medical MR Imaging.
Magnetite Nanoparticles for Medical MR Imaging.
复制标题
DOI：
10.1016/s1369-7021(11)70163-8
复制
发表时间：
2011-07
期刊：
影响因子：
24.2
通讯作者：
Zhang, Miqin
中科院分区：
文献类型：
--
作者：
Stephen, Zachary R.;Kievit, Forrest M.;Zhang, Miqin
纳米技术为科学家提供了开发用于检测和诊断疾病的先进材料的新工具。特别是氧化铁纳米颗粒（SPION）作为新型磁共振成像（MRI）造影剂已被广泛研究，因为它具有良好的超顺磁特性、生物可降解性和易于修饰的表面特性，可改善体内动力学和多功能性。本文讨论了 MR 成像的基础知识、SPION 独特磁特性的起源、用于检测 SPION 的 MRI 采集方法的最新进展、改善 SPION 成像特性的合成和合成后过程，以及 SPION 转化潜力的展望。
Nanotechnology has given scientists new tools for the development of advanced materials for the detection and diagnosis of disease. Iron oxide nanoparticles (SPIONs) in particular have been extensively investigated as novel magnetic resonance imaging (MRI) contrast agents due to a combination of favorable superparamagnetic properties, biodegradability, and surface properties of easy modification for improved in vivo kinetics and multifunctionality. This review discusses the basics of MR imaging, the origin of SPION’s unique magnetic properties, recent developments in MRI acquisition methods for detection of SPIONs, synthesis and post-synthesis processes that improve SPION’s imaging characteristics, and an outlook on the translational potential of SPIONs.