The CCL5/CCR5 Chemotactic Pathway Promotes Perineural Invasion in Salivary Adenoid Cystic Carcinoma
The CCL5/CCR5 Chemotactic Pathway Promotes Perineural Invasion in Salivary Adenoid Cystic Carcinoma
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DOI：
10.1016/j.joms.2018.02.009
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发表时间：
2018-08-01
影响因子：
1.9
通讯作者：
Sun, Moyi
中科院分区：
文献类型：
--
作者：
Gao, Tao;Shen, Zhiyuan;Sun, Moyi
Purpose: Perineural invasion (PNI) is a hallmark of salivary adenoid cystic carcinoma (SACC) and represents an important risk factor for local recurrence and poor survival. However, the mechanism of PNI has yet to be explored. We sought to examine the CCL5-CCR5 ligand-receptor interaction between nerves and SACC cells.Materials and Methods: CCL5/CCR5 expression was determined by immunohistochemistry in SACC tissue specimens. The correlations between CCL5/CCR5 expression and clinicopathologic features were investigated. Dorsal root ganglia (DRG) and SACC cells cocultured in vitro were used to evaluate the effects of CCL5/CCR5 on PNI progression and pathogenesis.Results: CCR5 expression was significantly elevated in SACC tissues and associated with distant metastasis, PNI, and TNM grade (P
