Immune-Activated Regional Lymph Nodes Predict Favorable Survival in Early-Stage Triple-Negative Breast Cancer.
Immune-Activated Regional Lymph Nodes Predict Favorable Survival in Early-Stage Triple-Negative Breast Cancer.
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免疫激活的区域淋巴结可预测早期三阴性乳腺癌的良好生存率。
DOI：
10.3389/fonc.2020.570981
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发表时间：
2020
影响因子：
4.7
通讯作者：
Yu KD
中科院分区：
文献类型：
--
作者：
Chen YY;Ge JY;Ma D;Yu KD
免疫应答和免疫治疗在三阴性乳腺癌（TNBC）中起着重要作用。然而，很难通过癌症本身来判断癌症是“免疫失活”还是“免疫激活”。微环境或宿主对肿瘤的免疫反应可能更具信息性。我们假设临床上肿大但病理学阴性的区域淋巴结可作为肿瘤早期免疫反应的指标。首先，我们从目前的监测、流行病学和最终结果数据库中确定了pN 0乳腺癌患者，并将cN 1患者的乳腺癌特异性生存期（BCSS）与cN 0患者进行了比较。然后，我们从来自12名TNBC患者、12名HER 2富集患者和12名管腔样患者的36对大淋巴结（定义为最小直径大于15 mm）和小淋巴结（定义为最大直径小于5 mm）中提取总RNA，并进行RNA测序，以探索与小淋巴结相比，大淋巴结的基因表达和细胞景观。在692例病理证实的淋巴结阴性疾病的女性中，与cN 0相比，cN 1患者在TNBC中的BCSS意外地更好（校正的风险比为0.148，95% CI，0.040-0.546，P = 0.004），但在其他亚型中并非如此。对来自TNBC患者的12对增大和小阴性淋巴结的进一步转录组测序显示，增加的免疫活化信号传导（例如，干扰素-γ反应途径）和大量免疫细胞（活化的树突状细胞、CD 4+和CD 8 + T细胞）在增大的淋巴结中更频繁地观察到。我们的数据表明，TNBC中局部淋巴结的早期免疫激活可能影响生存。
Immune response and immunotherapy play important roles in triple-negative breast cancer (TNBC). However, it is difficult to judge whether cancer is “immune-inactivated” or “immune-activated” by the carcinoma itself. The immune reaction of the microenvironment or the host to the tumor might be more informative. We assumed that clinically enlarged but pathologically negative regional lymph nodes served as an indicator for early immune response to tumors. First, we identified women with pN0 breast cancer disease from the current Surveillance, Epidemiology, and End Results database, and we compared the cN1 patients of breast cancer-specific survival (BCSS) with cN0 patients. Then, we extracted total RNA from 36 paired large (defined as minimum diameter more than 15 mm in size) and small lymph nodes (defined as maximum diameter less than 5 mm in size) from 12 TNBC, 12 HER2-enriched, and 12 luminal-like patients and performed RNA sequencing to explore the gene expression and cellular landscape of large nodes compared to small ones. Among 692 women with pathologically confirmed node-negative disease, cN1 patients unexpectedly had a better BCSS compared with cN0 in TNBC (adjusted hazard ratio 0.148, 95% CI, 0.040–0.546, P = 0.004) but not in other subtypes. Further transcriptome sequencing of 12 paired enlarged and small negative nodes from TNBC patients revealed that increased immune activation signaling (e.g., interferon-gamma response pathways) and abundant immune cells (activated dendritic cells, CD4+ and CD8+ T-cells) were more frequently observed in enlarged nodes. Our data implied that early immune activation in regional lymph nodes in TNBC might affect survival.
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三阴性乳腺癌的基因组和转录组景观：亚型和治疗策略
影响因子：
50.3
作者：
Jiang, Yi-Zhou;Ma, Ding;Shao, Zhi-Ming
通讯作者：
Shao, Zhi-Ming
多组学分析揭示了独特的微环境特征并提出了三阴性乳腺癌的免疫逃逸机制
影响因子：
11.5
作者：
Xiao, Yi;Ma, Ding;Shao, Zhi-Ming
通讯作者：
Shao, Zhi-Ming
DOI：
10.1056/nejmoa1200694
发表时间：
2012-06-28
期刊：
The New England journal of medicine
影响因子：
--
作者：
Brahmer JR;Tykodi SS;Chow LQ;Hwu WJ;Topalian SL;Hwu P;Drake CG;Camacho LH;Kauh J;Odunsi K;Pitot HC;Hamid O;Bhatia S;Martins R;Eaton K;Chen S;Salay TM;Alaparthy S;Grosso JF;Korman AJ;Parker SM;Agrawal S;Goldberg SM;Pardoll DM;Gupta A;Wigginton JM
通讯作者：
Wigginton JM
影响因子：
50.3
作者：
Topalian SL;Drake CG;Pardoll DM
通讯作者：
Pardoll DM
影响因子：
5.2
作者：
MORLAND, B
通讯作者：
MORLAND, B