Hyperthermic treatment of Bowen's disease with disposable chemical pocket warmers: a report of 8 cases.
Hyperthermic treatment of Bowen's disease with disposable chemical pocket warmers: a report of 8 cases.
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一次性化学暖袋热疗治疗鲍温病8例报告
DOI：
10.1067/mjd.2000.111351
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发表时间：
2000
影响因子：
13.8
通讯作者：
A. Kawada
中科院分区：
文献类型：
--
作者：
M. Hiruma;A. Kawada
鲍温氏病是一种原位鳞状细胞癌，局部热疗可能是有效的。我们对8例鲍温病患者进行了研究，以确定热疗是否能有效地对抗该病。以一次性化学保温器为热源，在患者清醒时直接加压于皮损部位，观察4~5个月的临床病程。然后切除病变并进行检查，以确定组织病理学影响。结果6例有效，结节状、浸润性病变及红斑片消退，皮损消失，色素沉积完全缓解。在一个病例中，体征改善了至少50%(部分缓解)；在另一个病例中，只有轻微的缓解(无反应)。3例肿瘤细胞消失，3例可见分离的肿瘤细胞，2例无变化。虽然治疗效果不理想，但代表了热疗的重大进步，是治疗鲍温病的有效方法之一。
Bowen's disease is a form of squamous cell carcinoma in situ, in which local hyperthermia may be efficacious. We studied 8 patients with Bowen's disease to ascertain whether hyperthermia can be effective against it. As a heat source, disposable chemical pocket warmers were applied daily with pressure directly to the lesion site while the patient was awake, and the clinical course was observed for 4 to 5 months. The lesion was then excised and examined to determine the histopathologic effects. The results showed efficacy in 6 cases, in which the nodular and invasive lesions and the erythematous patches abated; then the lesions disappeared, leaving deposits of pigment (complete remission). In one case, the signs improved by at least 50% (partial remission); in the other case, there was only slight palliation (no response). As for the posttreatment histopathologic effects, tumor cells were eliminated in 3 cases, isolated tumor cells were seen in 3 cases, and there was no change in 2. Although the treatment did not yield perfect results, it represents a major improvement of hyperthermic therapy and is one effective method of treating Bowen's disease.