Construction and application of targeted drug delivery system based on hyaluronic acid and heparin functionalised carbon dots
Construction and application of targeted drug delivery system based on hyaluronic acid and heparin functionalised carbon dots
复制标题
基于透明质酸和肝素功能化碳点的靶向给药系统的构建及应用
DOI：
10.1016/j.colsurfb.2019.110768
复制
发表时间：
2020-04-01
影响因子：
5.8
通讯作者：
Sang, Shengbo
中科院分区：
文献类型：
--
作者：
Duan, Qianqian;Ma, Lan;Sang, Shengbo
血栓形成是癌症的主要并发症。它可以增加癌症患者的死亡率。因此，将抗凝剂肝素（Hep）作为辅助治疗剂引入到基于盐酸阿霉素（DOX）-碳量子点（CD）-透明质酸（HA）的给药系统中，明显增强了系统的血液相容性。CDs-HA-Hep/DOX系统的药物释放过程是HA和pH值双重响应的。体外MTT和划痕实验结果表明，该药物缓释系统能靶向抑制癌细胞的生长和迁移。此外，该系统还可以根据CD的荧光对药物进行视觉跟踪。
Thrombosis is a main complication of cancer. It can increase the mortality of cancer patients. Therefore, the anticoagulant heparin (Hep) as an adjuvant therapy was introduced to the drug delivery system based on doxorubicin hydrochloride (DOX)-carbon dots (CDs)-Hyaluronic acid (HA), which obviously enhanced the blood compatibility of the system. Drug release process of the CDs-HA-Hep/DOX system was dual-responsive by HA and pH value. Results of in vitro MTT and scratch tests demonstrated that the drug delivery system could targetedly inhibit growth and migration of cancerous cells. In addition, the system allows visual tracking of the drug based on fluorescence of CDs.