Hormonally induced renal neoplasia in the male Syrian hamster and the inhibitory effect of 2-bromo-alpha-ergocryptine methanesulfonate.
Hormonally induced renal neoplasia in the male Syrian hamster and the inhibitory effect of 2-bromo-alpha-ergocryptine methanesulfonate.
复制标题
雄性叙利亚仓鼠激素诱导的肾肿瘤和 2-溴-α-麦角隐亭甲磺酸盐的抑制作用。
DOI：
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发表时间：
1975
期刊：
影响因子：
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通讯作者：
S. Maguire
中科院分区：
文献类型：
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作者：
J. M. Hamilton;A. Flaks;P. G. Saluja;S. Maguire
一组雄性叙利亚仓鼠在 9 个月的时间内接受了己烯雌酚 (DES)。所有患者均出现广泛且严重的肾肿瘤。另一组雄性叙利亚仓鼠在同一时期接受 DES 加 2-溴-α-麦角隐亭甲磺酸盐 (CB154)。这些仓鼠要么没有患上肾肿瘤，要么患有严重程度最低的肾肿瘤。 DES治疗引起治疗动物垂体中叶的增生性和肿瘤性变化，增加催乳素分泌细胞的数量，并减少生长激素分泌细胞的数量。添加 CB154 显着抑制垂体的这些变化。组织病理学和超微结构检查表明肾肿瘤是起源于近曲小管的癌。
One group of male Syrian hamsters received diethylstilbestrol (DES) over a period of 9 months. All developed widespread and severe renal tumors. Another group of male Syrian hamsters was given DES plus 2-bromo-alpha-ergocryptine methanesulfonate (CB154) over the same period. These hamsters either did not develop renal tumors or had renal tumors that were minimal in severity. DES treatment induced hyperplastic and neoplastic changes in the intermediate lobe of the pituitary glands of treated animals, increased the number of prolactin-secreting cells, and decreased the number of somatotrophin-secreting cells. Adding CB154 significantly inhibited those changes in the pituitary gland. Histopathologic and ultrastructural examinations indicated that the renal tumors were carcinomas originating from proximal convoluted tubules.