Systemic uric acid administration increases serum antioxidant capacity in healthy volunteers
Systemic uric acid administration increases serum antioxidant capacity in healthy volunteers
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DOI：
10.1097/00005344-200109000-00005
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发表时间：
2001-09-01
影响因子：
3
通讯作者：
Maxwell, SRJ
中科院分区：
文献类型：
--
作者：
Waring, WS;Webb, DJ;Maxwell, SRJ
氧化应激在动脉粥样硬化的发展中起着重要作用，并导致组织损伤，特别是在心肌梗死和急性中风中。尿酸的抗氧化作用早已得到认可，由于其较高的血清浓度，它是人类体内最丰富的自由基清除剂。例如，血清尿酸浓度升高是对氧化应激增加的生理反应。在急性运动期间--从而提供了抗氧化剂防御的反调节增加。鉴于其抗氧化特性，尿酸可能在心血管系统中具有潜在的重要和有益的作用。我们希望调查尿酸给药是否可行，以及它是否会对体内的抗氧化功能产生影响。因此，我们进行了一项随机、安慰剂对照的双盲研究，以了解全身应用尿酸的效果。健康志愿者为1,000毫克，而维生素C为1,000毫克。我们使用两种方法学上不同的抗氧化剂分析，观察到在尿酸和维生素C输注期间，血清清除自由基的能力较基线显著增加。尿酸的影响比维生素C大得多。
Oxidative stress plays an important role in the development of atherosclerosis and contributes to tissue damage that occurs as a consequence, particularly in myocardial infarction and acute stroke. Antioxidant propel-ties of uric acid have long been recognized and, as a result of its comparatively high serum concentrations, it is the most abundant scavenger of free radicals in humans. Elevation of serum uric acid concentration occurs as a physiologic response to increased oxidative stress-for example. during acute exercise-thus providing a counter-regulatory increase in antioxidant defenses. In view of its antioxidant properties, uric acid may have potentially important and beneficial effects within the cardiovascular system. We wished to investigate whether administration of uric acid was feasible and if it could have an impact on antioxidant function in vivo. We have, therefore, performed a randomized, placebo-controlled double-blind study of the effects of systemic administration of uric acid. 1,000 mg, in healthy volunteers, compared with vitamin C, 1,000 mg. We observed a significant increase in serum free-radical scavenging capacity from baseline during uric acid and vitamin C infusion, using two methodologically distinct antioxidant assays. The effect of uric acid was substantially greater than that of vitamin C.