Preparative Enantioseparation of dl‐α‐Methylbenzylamine by High-Speed Countercurrent Chromatography using l‐(+)‐Tartaric Acid as Chiral Selector
Preparative Enantioseparation of dl‐α‐Methylbenzylamine by High-Speed Countercurrent Chromatography using l‐(+)‐Tartaric Acid as Chiral Selector
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DOI：
10.1080/10826070701277133
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发表时间：
2007-04
影响因子：
1.3
通讯作者：
Y. Cai;Z. Yan;M. Zi;L. Yuan
中科院分区：
文献类型：
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作者：
Y. Cai;Z. Yan;M. Zi;L. Yuan
以l‐（+）‐酒石酸为手性选择剂，采用高速逆流色谱法分离dl‐α‐甲基苄胺对映体。选择氯仿：甲醇：水=4:3:1的两相体系，上相含278 mmol/L手性选择剂。一次进样最多可达120毫克。分离得到的对映体经薄层色谱和手性高效液相色谱鉴定，证实了该方法用于手性制剂分离是可行的。这是首次报道l‐（+）‐酒石酸被用作HSCCC的手性选择剂。
Abstract Enantiomers of dl‐alpha‐methylbenzylamine were separated by high-speed countercurrent chromatography using l‐(+)‐tartaric acid as a chiral selector. The two phases system composed of chloroform:methanol:water=4:3:1 was chosen, which contained 278 mmol/L of chiral selector in the upper phase. The maximum of sample in a one time injection can be up to 120 mg. The enantiomers separated were identified by TLC and chiral HPLC, which confirmed that the method was very feasible for chiral preparative separation. This is the first report that l‐(+)‐tartaric acid was used as a chiral selector in the HSCCC.