A prospective study of calcium intake from diet and supplements and risk of ischemic heart disease among men
A prospective study of calcium intake from diet and supplements and risk of ischemic heart disease among men
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DOI：
10.1093/ajcn/77.4.814
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发表时间：
2003-04-01
影响因子：
7.1
通讯作者：
Hu, FB
中科院分区：
文献类型：
--
作者：
Al-Delaimy, WK;Rimm, E;Hu, FB
背景：钙摄入量被认为对患缺血性心脏病 (IHD) 的风险具有保护作用，但现有数据不一致。目的：目的是评估男性中钙摄入量与 IHD 风险之间的关系。设计：健康专业人员随访研究中对 1986 年返回饮食问卷的男性 (n = 39 800) 进行了为期 12 年的随访。 1986 年、1990 年和 1994 年对钙和其他营养素的摄入量进行了评估。总 IHD（非致命性心肌梗死和致命性 IHD）发生率的终点通过病历审查确定。其他 IHD 危险因素每两年记录一次。结果：在 12 年的随访期间（415 965 人年），我们记录了 1458 例 IHD 病例：1030 例非致命性心肌梗死和 428 例致命性 IHD。在控制标准 IHD 危险因素后，与钙摄入五分位数最低（中位摄入量 = 1377 毫克/天）的男性相比，钙摄入量最低（中位摄入量 = 523 毫克/天）的男性患 IHD 的相对风险为 0.97（95% CI：0.81, 1.16；趋势 P = 0.64），维生素 D 摄入量为 1.00（95% CI：0.80， 1.24； 趋势 = 0.66），乳制品总摄入量为 1.01（95% CI：0.83，1.23；趋势 P = 0.57）。对于补充钙摄入量而言，最高五分位数与未服用补充剂的人相比，患 IHD 的相对风险为 0.87（95% CI：0.64, 1.19；趋势 P = 0.31）。 结论：结果表明，无论是饮食还是补充钙摄入量均与男性患 IHD 的风险没有显着相关。
Background: Calcium intake is thought to have a protective effect on the risk of developing ischemic heart disease (IHD), but the existing data are inconsistent.Objective: The objective was to assess the relation between calcium intake and risk of IHD among men.Design: Men in the Health Professionals Follow-up Study who returned a dietary questionnaire in 1986 (n = 39 800) were followed up for 12 y. Intakes of calcium and other nutrients were assessed in 1986, 1990, and 1994. The endpoints of total IHD (nonfatal myocardial infarction and fatal IHD) incidence were ascertained by medical record review. Other IHD risk factors were recorded biennially.Results: During 12 y of follow-up (415 965 person-years), we documented 1458 cases of IHD: 1030 of nonfatal myocardial infarction and 428 of fatal IHD. After control for standard IHD risk factors, the relative risk of developing IHD among men in the highest (median intake = 1377 mg/d) compared with the lowest (median intake = 523 mg/d) calcium intake quintile was 0.97 (95% CI: 0.81, 1.16; P for trend = 0.64), for vitamin D intake was 1.00 (95% CI: 0.80, 1.24; P for trend = 0.66), and for total dairy product intake was 1.01 (95% CI: 0.83, 1.23; P for trend = 0.57). For supplemental calcium intake, the relative risk of developing IHD in a comparison of the highest quintile with nonusers of supplements was 0.87 (95% CI: 0.64, 1.19; P for trend = 0.31).Conclusion: The results suggest that neither dietary nor supplemental intakes of calcium are appreciably associated with the risk of IHD among men.