Measures of placental growth in relation to birth weight and gestational age
Measures of placental growth in relation to birth weight and gestational age
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DOI：
10.1093/aje/kwi305
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发表时间：
2005-11-15
影响因子：
5
通讯作者：
Savitz, DA
中科院分区：
文献类型：
--
作者：
Salafia, CM;Maas, E;Savitz, DA
胎儿的生长部分取决于胎盘的生长。作者测试了来自数字图像的胎盘测量的可靠性，并评估了它们与出生体重和胎龄的关系。共有628名妇女参加了妊娠、感染和营养研究，这是一项2002年至2004年在北卡罗来纳州中部进行的早产前瞻性队列研究，在妊娠24周后分娩了单胎活产婴儿。新的绒毛膜板形态测量参数捕获的数字图像的总胎盘进行了分析，估计胎龄和出生体重。在不承认胎盘重量的情况下，数字化获得的侧绒毛膜板生长测量值占胎龄差异的17%和出生体重差异的35%。绒毛膜板测量值占出生体重差异的10%，超过了单独胎盘重量的解释。在早产儿中，34%的胎龄差异和63%的出生体重差异是由侧绒毛膜板生长测量结果引起的。新的数字措施的组内相关系数范围为0.96至0.98。侧绒毛板生长的可靠数字测量估计出生体重差异比胎龄更强，项目方差不占胎盘重量，并预测这些结果在早产比在足月更大的程度。
Fetal growth depends in part on placental growth. The authors tested placental measures derived from digital images for reliability and to evaluate their association with birth weight and gestational age. A total of 628 women recruited into the Pregnancy, Infection, and Nutrition Study, a prospective cohort study of preterm birth in central North Carolina between 2002 and 2004, delivered singleton liveborn infants after 24 completed weeks' gestation. Novel chorionic plate morphometric parameters captured off digital images of the gross placenta were analyzed as estimators of gestational age and birth weight. Without acknowledgment to placental weight, digitally obtained lateral chorionic plate growth measures accounted for 17 percent of gestational age variance and 35 percent of birth weight variance, overall. Chorionic plate measures accounted for 10 percent of birth weight variance beyond that accounted for by placental weight alone. Among preterm births, 34 percent of gestational age variance and 63 percent of birth weight variance were accounted for by lateral chorionic plate growth measures. Intraclass correlation coefficients for the novel digital measures ranged from 0.96 to 0.98. Reliable digital measures of lateral chorionic plate growth estimate birth weight variance more strongly than gestational age, project variance that is not accounted for by placental weight, and project these outcomes to a greater degree in preterm births than at term.