Long-term effects of web-based pedometer-mediated intervention on COPD exacerbations.
Long-term effects of web-based pedometer-mediated intervention on COPD exacerbations.
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DOI：
10.1016/j.rmed.2020.105878
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发表时间：
2020-02
影响因子：
4.3
通讯作者：
E. Wan;A. Kantorowski;Madeline Polak;Reema Kadri;C. Richardson;D. Gagnon;E. Garshick;M. Moy
中科院分区：
文献类型：
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作者：
E. Wan;A. Kantorowski;Madeline Polak;Reema Kadri;C. Richardson;D. Gagnon;E. Garshick;M. Moy
背景技术为基础的体力活动（PA）干预已被证明可以改善每日步数和健康相关的生活质量，但其对COPD患者急性加重（AE）等长期临床结局的影响尚不清楚。患有稳定COPD的退伍军人被随机（1：1）分配到单独的计步器（对照组）或计步器加反馈，目标设定，疾病教育和社区论坛（干预）的网站3个月。在约15个月的随访期内，每3个月评估一次AE。在基线、3个月干预结束时以及入组后约6个月和12个月的随访期间，对计步器评估的每日步数、健康相关生活质量（HRQL）和自我效能进行评估。零膨胀泊松模型评估了与对照组相比，干预对AE风险的影响。广义线性混合效应模型的重复测量检查组间和组内的变化，每日步数，HRQL，和self-efficiency.ResultsThere年龄，FEV1%预测，基线每日步数，AE前一年登记，或干预组（n = 57）和对照组（n = 52）之间的随访时间没有显着差异。与对照组相比，干预组的AE风险显著降低（率比= 0.51，[95%CI 0.31-0.85]）。平均每日步数，HRQL，或自我效能在6个月和12个月后enrollment.ConclusionsA 3个月的互联网介导的，基于计步器的PA干预的变化没有显着的组间差异与降低风险的COPD AE超过12-15个月的follow-up.ClinicalTrials.gov标识符：NCT 01772082。
BackgroundTechnology-based physical activity (PA) interventions have been shown to improve daily step counts and health-related quality of life, but their effect on long-term clinical outcomes like acute exacerbations (AEs) is unknown in persons with COPD.MethodsU.S. Veterans with stable COPD were randomized (1:1) to either pedometer alone (control) or pedometer plus a website with feedback, goal-setting, disease education, and a community forum (intervention) for 3 months. AEs were assessed every 3 months over a follow-up period of approximately 15 months. Pedometer-assessed daily step counts, health-related quality-of-life (HRQL), and self-efficacy were assessed at baseline, end-of-intervention at 3 months, and during follow-up approximately 6 and 12 months after enrollment. Zero-inflated Poisson models assessed the effect of the intervention on risk for AEs, compared to controls. Generalized linear mixed-effects models for repeated measures examined between-group and within-group changes in daily step count, HRQL, and self-efficacy.ResultsThere were no significant differences in age, FEV1% predicted, baseline daily step count, AEs the year prior to enrollment, or duration of follow-up between the intervention (n = 57) and control (n = 52) groups. The intervention group had a significantly reduced risk of AEs (rate ratio = 0.51, [95%CI 0.31–0.85]), compared to the control group. There were no significant between-group differences in change in average daily step count, HRQL, or self-efficacy at 6 and 12 months after enrollment.ConclusionsA 3-month internet-mediated, pedometer-based PA intervention was associated with reduced risk for AEs of COPD over 12–15 months of follow-up.ClinicalTrials.gov identifier: NCT01772082.