Steady‐state Pharmacokinetics of Lamotrigine when Converting from a Twice‐daily Immediate‐release to a Once‐daily Extended‐release Formulation in Subjects with Epilepsy (The COMPASS Study)
Steady‐state Pharmacokinetics of Lamotrigine when Converting from a Twice‐daily Immediate‐release to a Once‐daily Extended‐release Formulation in Subjects with Epilepsy (The COMPASS Study)
复制标题
癫痫患者从每日两次立即释放制剂转换为每日一次缓释制剂时拉莫三嗪的稳态药代动力学（COMPASS 研究）
DOI：
10.1111/j.1528-1167.2007.01274.x
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发表时间：
2008
期刊：
影响因子：
5.6
通讯作者：
J. Messenheimer
中科院分区：
文献类型：
--
作者：
D. Tompson;I. Ali;Ruth Oliver;S. Job;Li Zhu;Francesca Lemme;A. Hammer;A. Vuong;J. Messenheimer
目的：在癫痫受试者中比较拉莫三嗪（LTG）从每日两次速释（LTG‐IR）转换为每日一次缓释（LTG‐XR）时的药代动力学（PK）。
Purpose: To compare the pharmacokinetics (PK) of lamotrigine (LTG) when converting from twice‐daily immediate‐release (LTG‐IR) to once‐daily extended‐release (LTG‐XR) in subjects with epilepsy.