Modeling the dynamics of tamponade multicomponent gases during retina reattachment surgery
Modeling the dynamics of tamponade multicomponent gases during retina reattachment surgery
复制标题
视网膜复位手术期间填充多组分气体的动力学建模
DOI：
10.1002/aic.15739
复制
发表时间：
2017
期刊：
影响因子：
3.7
通讯作者：
Hall S
中科院分区：
文献类型：
--
作者：
Hall S
玻璃体切除术和充气性视网膜固定术是用于治疗视网膜脱离的常见外科手术。为了重新附着视网膜，使用气体来使玻璃体空间膨胀，从而允许视网膜通过上级气泡位置的表面张力和浮力附着。这些手术需要注入纯的填塞气体，如C3 F8或SF6，或这些气体与空气的混合物。视网膜脱离的位置、视网膜缺损的解剖学分布以及缺损持续的时间长度将决定气泡的建议体积和持续时间，以允许重新附着。充气后，气体被血液缓慢吸收，允许玻璃体被水重新填充。我们已经开发了一个模型，在充气视网膜固定术或睫状体平坦部玻璃体切除术过程中，填塞气体的传质动力学。该模型预测了眼内气体（C3 F8，SF6），氧气，氮气和二氧化碳的膨胀和持久性，以及眼内压。该模型使用已发表的文献在兔和人中进行了验证。除了通过表面积、渗透性和分压驱动力关联传质动力学之外，传质动力学还受到填塞气体的百分比的影响。发生率还与填塞物的物理性质和血气有关。该模型对人类进行了准确的预测。© 2017美国化学工程师学会AIChE J，63：3651-3662，2017
Vitrectomy and pneumatic retinopexy are common surgical procedures used to treat retinal detachment. To reattach the retina, gases are used to inflate the vitreous space allowing the retina to attach by surface tension and buoyancy forces that are superior to the location of the bubble. These procedures require the injection of either a pure tamponade gas, such as C3F8or SF6, or mixtures of these gases with air. The location of the retinal detachment, the anatomical spread of the retinal defect, and the length of time the defect has persisted, will determine the suggested volume and duration of the gas bubble to allow reattachment. After inflation, the gases are slowly absorbed by the blood allowing the vitreous to be refilled by aqueous. We have developed a model of the mass transfer dynamics of tamponade gases during pneumatic retinopexy or pars plana vitrectomy procedures. The model predicts the expansion and persistence of intraocular gases (C3F8, SF6), oxygen, nitrogen, and carbon dioxide, as well as the intraocular pressure. The model was validated using published literature in rabbits and humans. In addition to correlating the mass transfer dynamics by surface area, permeability, and partial pressure driving forces, the mass transfer dynamics are affected by the percentage of the tamponade gases. Rates were also correlated with the physical properties of the tamponade and blood gases. The model gave accurate predictions in humans. © 2017 American Institute of Chemical EngineersAIChE J, 63: 3651–3662, 2017