Longitudinal relaxation times of 129Xe in rat tissue homogenates at 9.4 T
Longitudinal relaxation times of 129Xe in rat tissue homogenates at 9.4 T
复制标题
9.4 T 下大鼠组织匀浆中 129Xe 的纵向弛豫时间
DOI：
--
复制
发表时间：
1999
影响因子：
3.3
通讯作者：
P. Deluca
中科院分区：
文献类型：
--
作者：
G. Wilson;G. Santyr;M. Anderson;P. Deluca
测量了不同氧合水平下大鼠脑、肾、肝和肺组织匀浆中129Xe的纵向弛豫时间，以评估以激光偏振(LP)129Xe为信号源进行组织磁共振成像的可行性。测得的松弛时间在无氧肺匀浆4.4±0.4秒至无氧脑匀浆22±2秒之间。当通过吸入将LP气体引入受试者时，这些弛豫时间足够长，以允许在组织中积累LP 129Xe并随后进行MR成像。溶解的LP 129Xe的成像将产生大约为质子本征信噪比的3%的本征信噪比(SNR)。这种相对较低的本征信噪比有望满足某些示踪剂的应用。发现129Xe的T1值取决于组织的氧合水平，而氧合的效果可能取决于组织匀浆中的血红蛋白含量。医学杂志41：933-938,1999。©1999 Wiley-Liss，Inc.
Longitudinal relaxation times of 129Xe were measured in homogenates of rat brain, kidney, liver, and lung at varying oxygenation levels as a means to assess the feasibility of magnetic resonance (MR) imaging of tissue using laser‐polarized (LP) 129Xe as the signal source. The measured relaxation times ranged from 4.4 ± 0.4 sec in deoxygenated lung homogenate to 22 ± 2 sec in deoxygenated brain homogenate. When the LP gas is introduced to the subject via inhalation, these relaxation times are long enough to allow accumulation and subsequent MR imaging of LP 129Xe in tissues. Imaging of dissolved LP 129Xe will yield an intrinsic signal‐to‐noise ratio (SNR) that is approximately 3% of the proton intrinsic SNR. This relatively low intrinsic SNR is expected to be adequate for some tracer applications. T1 of 129Xe was found to depend on the oxygenation level of the tissue, and the effect of oxygenation is likely dependent on the amount of hemoglobin in the tissue homogenate. Magn Reson Med 41:933–938, 1999. © 1999 Wiley‐Liss, Inc.