Robust alginate/hyaluronic acid thiol-yne click-hydrogel scaffolds with superior mechanical performance and stability for load-bearing soft tissue engineering
Robust alginate/hyaluronic acid thiol-yne click-hydrogel scaffolds with superior mechanical performance and stability for load-bearing soft tissue engineering
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DOI：
10.1039/c9bm01494b
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发表时间：
2020-01-01
影响因子：
6.6
通讯作者：
Dove, Andrew P.
中科院分区：
文献类型：
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作者：
Perez-Madrigal, Maria M.;Shaw, Joshua E.;Dove, Andrew P.
基于透明质酸(HA)的水凝胶因其独特的生物学特性而显示出作为组织工程支架的巨大潜力。在这里，我们研究了两种天然聚合物(即HA和海藻酸盐)的优点如何与硫醇-炔点击化学反应的高效和快速性质相结合，以获得具有定制性能的生物相容性基质。我们的可注射点击水凝胶表现出优异的机械性能、长期稳定性、高细胞相容性和足够的硬度，可用于靶向应用。这种简单的方法产生了HA水凝胶，其特性使其适合作为3D支架应用，以支持和促进软组织再生。
Hydrogels based on hyaluronic acid (HA) exhibit great potential as tissue engineering (TE) scaffolds as a consequence of their unique biological features. Herein, we examine how the advantages of two natural polymers (i.e. HA and alginate) are combined with the efficiency and rapid nature of the thiol-yne click chemistry reaction to obtain biocompatible matrices with tailored properties. Our injectable click-hydrogels revealed excellent mechanical performance, long-term stability, high cytocompatibility and adequate stiffness for the targeted application. This simple approach yielded HA hydrogels with characteristics that make them suitable for applications as 3D scaffolds to support and promote soft tissue regeneration.