Grob-type fragmentation of an oxonium ylide generated from alpha-imino rhodium carbene
Grob-type fragmentation of an oxonium ylide generated from alpha-imino rhodium carbene
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由 α-亚氨基铑卡宾生成的氧鎓叶立德的 Grob 型裂解
DOI：
10.1039/d1qo01226f
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发表时间：
2021
影响因子：
5.4
通讯作者：
Li Chuan-Ying
中科院分区：
文献类型：
--
作者：
Chen Tao;Yan Zhenxing;Duan Shengguo;Xu Ze-Feng;Li Chuan-Ying
实现了氧与α-亚氨基铑卡宾分子内加成生成的氧鎓叶立德的Grob型断裂。该反应是立体特异性的，并产生两个远程双键。新形成的双键可以用作进一步转化的有用的合成柄。通过初步的对比实验，并对起始三唑类化合物与产物的立体化学进行了比较，提出了合理的反应机理。
A Grob-type fragmentation of an oxonium ylide generated from the intramolecular addition of oxygen to α-imino rhodium carbene was realized. The reaction was stereospecific and produced two remote double bonds. The newly formed double bonds could be employed as useful synthetic handles for further transformations. A reasonable mechanism was proposed based on primary control experiments and comparison of the stereochemistry of the starting triazoles with that of the products.