ENZYMATIC AND NONENZYMATIC CROSS-LINKING OF COLLAGEN AND ELASTIN
ENZYMATIC AND NONENZYMATIC CROSS-LINKING OF COLLAGEN AND ELASTIN
复制标题
DOI：
10.1096/fasebj.6.7.1348714
复制
发表时间：
1992-04-01
期刊：
影响因子：
4.8
通讯作者：
RUCKER, RB
中科院分区：
文献类型：
--
作者：
REISER, K;MCCORMICK, RJ;RUCKER, RB
在过去的30年里，关于胶原蛋白和弹性蛋白的链内和链间交联的步骤和机制的知识已经稳步发展。最近，努力已被定向在确定的胶原蛋白和弹性蛋白中发现的交联的位置和类型。有两大类交联：由赖氨酰氧化酶引发的交联和由非酶糖化赖氨酸和羟基赖氨酸残基衍生的交联。酶交联的形成取决于特定的酶、氨基酸序列和四级结构排列。非酶促产生的交联更偶然发生，对病理生物学过程很重要。在阐明几种酶介导的交联的合成途径以及调节交联特异性的可能机制方面已经取得了相当大的进展。虽然不太知道的化学交联所产生的非酶糖化残基，最近的进展也取得了理解可能的生物合成途径和控制机制。本文综述了这些进展，并希望强调胶原和弹性蛋白交联的生物学重要性。
Knowledge regarding the steps and mechanisms related to the intra- and interchain cross-linking of collagen and elastin has evolved steadily during the past 30 years. Recently, effort has been directed at identifying the location and types of cross-links that are found in collagen and elastin. There are two major groups of cross-links: those initiated by the enzyme lysyl oxidase and those derived from nonenzymatically glycated lysine and hydroxylysine residues. The formation of enzymatic cross-links depends on specific enzymes, amino acid sequences, and quaternary structural arrangements. The cross-links that are derived nonenzymatically occur more adventitiously and are important to pathobiological processes. Considerable progress has been made in elucidating the pathways of synthesis for several of the enzymatically mediated cross-links, as well as possible mechanisms regulating the specificity of cross-linking. Although less is known about the chemistry of cross-links arising from nonenzymatically glycated residues, recent progress has also been made in understanding possible biosynthetic pathways and control mechanisms. This review focuses on such progress and hopes to underscore the biological importance of collagen and elastin cross-linking.