Prognostic factors in influenza-associated encephalopathy
Prognostic factors in influenza-associated encephalopathy
复制标题
DOI：
10.1097/inf.0b013e318162a13b
复制
发表时间：
2008-05-01
影响因子：
3.6
通讯作者：
Okabe, Nobuhiko
中科院分区：
文献类型：
--
作者：
Nagao, Takashi;Morishima, Tsuneo;Okabe, Nobuhiko
背景：近年来，全球范围内流感相关脑病的报告有所增加。鉴于流感的严重神经系统并发症导致的高死亡率和发病率，我们在日本进行了一项全国性的研究，以确定预后因素。方法：我们回顾性评估了442例流感相关脑病病例，这些病例报告给了流感相关脑病协作研究组，该研究组由日本厚生劳动省组织，1998年至2002年，与日本的医院、诊所和当地儿科诊所合作。每例患者的结局分为生存或死亡。结果：通过多因素分析，发现四个主要的死亡预后因素是显著的（P < 0.05）在184例我们有完整数据的患者中：天冬氨酸转氨酶升高、高血糖、血尿或蛋白尿的存在以及双氯芬酸钠的使用。我们确定了与预后不良相关的患者，这些发现可能对这种疾病的治疗有临床意义。
Background: Recently, reports of influenza-associated encephalopathy have increased worldwide. Given the high mortality and morbidity rates attributable to this severe neurologic complication of influenza, we conducted a nationwide study in Japan to identify the prognostic factors.Methods: We retrospectively evaluated 442 cases of influenza-associated encephalopathy that were reported to the Collaborative Study Group on Influenza-Associated Encephalopathy, which was organized by the Japanese Ministry of Health, Labor, and Welfare in collaboration with hospitals, clinics, and local pediatric practices in Japan between 1998 and 2002. The outcome for each patient was classified as either survival or death. Predictors of death were identified using logistic regression analysis.Results: Four major prognostic factors for death were found to be significant by multivariate analysis (P < 0.05) in the 184 patients for whom we had complete data: elevation of aspartate aminotransferase, hyperglycemia, the presence of hematuria or proteinuria, and use of diclofenac sodium.Conclusions: We identified patients who had factors associated with a poor prognosis, and these findings might be clinically useful for the management of this illness.