Fibroblasts and myofibroblasts: Their source, function and role in disease
Fibroblasts and myofibroblasts: Their source, function and role in disease
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DOI：
10.1016/j.biocel.2006.11.005
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发表时间：
2007-01-01
影响因子：
4
通讯作者：
McAnulty, Robin J.
中科院分区：
文献类型：
--
作者：
McAnulty, Robin J.
成纤维细胞存在于身体的大多数组织中。它们表现出几种表型，包括非收缩性成纤维细胞、收缩性肌成纤维细胞和中间表型，包括原肌成纤维细胞。成纤维细胞是具有代谢活性的细胞，其在调节细胞外基质、间质液体积和压力以及伤口愈合中起关键作用。成纤维细胞的数量可以通过居民群体的增殖来维持或扩增，但此外，最近的证据表明它们也可以通过上皮-间充质转化或从循环和组织来源的间充质干细胞获得。许多疾病与损伤修复反应和成纤维细胞功能的失调有关，导致细胞外基质蛋白沉积增加或减少，组织结构改变，功能受损，并且在某些情况下显著发病率和死亡率。目前还没有靶向成纤维细胞相关病理学的特异性疗法，但对病理学机制的了解不断增加，导致了新药物的开发，为改善这些疾病的治疗提供了希望。(c)2006爱思唯尔有限公司保留所有权利。
Fibroblasts are found in most tissues of the body. They exhibit several phenotypes including non-contractile fibroblasts, contractile myofibroblasts, and intermediate phenotypes including the protomyofibroblast. Fibroblasts are metabolically active cells which play critical roles regulating extracellular matrices, interstitial fluid volume and pressure, and wound healing. Fibroblast numbers can be maintained or expanded by proliferation of resident populations but in addition, recent evidence indicates they can also be derived through epithelial-mesenchymal transition or from circulating and tissue-derived mesenchymal stem cells. Many diseases are associated with dysregulation of the injury repair response and fibroblast function, leading to increased or decreased deposition of extracellular matrix proteins, altered tissue architecture, impaired function and in some cases significant morbidity and mortality. There are currently no specific therapies that target fibroblast-associated pathology but increasing knowledge of pathological mechanisms has led to development of new agents providing hope for improved treatment of these diseases. (c) 2006 Elsevier Ltd. All rights reserved.