Vesicular degradation pathways in neurons: at the crossroads of autophagy and endo-lysosomal degradation
Vesicular degradation pathways in neurons: at the crossroads of autophagy and endo-lysosomal degradation
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DOI：
10.1016/j.conb.2019.01.005
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发表时间：
2019-08-01
影响因子：
5.7
通讯作者：
Holzbaur, Erika L. F.
中科院分区：
文献类型：
--
作者：
Boecker, C. Alexander;Holzbaur, Erika L. F.
自噬和内溶酶体降解是维持神经元健康和功能所必需的两种平行降解途径。自噬体和核内体通过不同的机制隔离细胞货物，但这些途径在与溶酶体融合时收敛。这两种通路都受空间调控，在胞体、轴突和树突中具有明显的不同特征，可能是为了适应神经元的独特形态和每个隔室的特定需求。关于自噬和内溶酶体降解如何相互作用的了解相对较少。以及如何协调他们的活动。我们回顾了我们目前对神经元中自噬和内溶酶体降解的理解，强调了这两种基本细胞途径的共同特征和差异以及交集。
Autophagy and endo-lysosomal degradation are two parallel degradation pathways essential for maintaining neuronal health and function. Autophagosomes and endosomes sequester cellular cargo through different mechanisms, but these pathways converge upon fusion with lysosomes. Both pathways are spatially regulated, with distinct features evident in the soma, axons, and dendrites, possibly as an adaptation to the unique morphology of neurons and the specific demands of each compartment. Relatively little is known about how autophagy and endo-lysosomal degradation interact. and how their activities may be coordinated. We review our current understanding of autophagy and endo-lysosomal degradation in neurons, highlighting common features and differences as well as the intersection of these two essential cellular pathways.