Cerebral physiological and metabolic effects of hyperventilation in the neonatal dog.
Cerebral physiological and metabolic effects of hyperventilation in the neonatal dog.
复制标题
新生犬过度换气对大脑生理和代谢的影响。
DOI：
10.1002/ana.410160310
复制
发表时间：
1984
影响因子：
11.2
通讯作者：
Yagel,SK
中科院分区：
文献类型：
--
作者：
Young,RS;Yagel,SK
为了阐明新生儿明显低碳酸血症期间发生的变化，我们测量了新生犬过度通气90分钟后的脑血流量和代谢物水平。间脑、脑干和脊髓的脑血流量显著减少，但大脑皮质或白色物质无明显变化。脑电图没有实质性变化。端脑和上级矢状窦血液中的乳酸浓度显著增加，尽管ATP或磷酸肌酸水平没有改变。新生犬明显的低碳酸血症导致脑乳酸水平升高，这可能与糖酵解速率的变化有关，而与组织缺血或缺氧无关。
To clarify the changes that occur during marked hypocarbia in the neonate, we measured brain blood flow and metabolite levels after 90 minutes of hyperventilation in neonatal dogs. Brain blood flow decreased significantly in diencephalon, brainstem, and spinal cord but not in cerebral cortex or white matter. There was no substantial change in the electroencephalogram. Lactate concentrations, both in telencephalon and in superior sagittal sinus blood, increased significantly, although there was no alteration in levels of ATP or phosphocreatine. Marked hypocarbia in the neonatal dog produces an elevated brain lactate level that may be related to changes in glycolytic rate rather than to tissue ischemia or hypoxia.