Tissue-engineered cultured periosteum used with platelet-rich plasma and hydroxyapatite in treating human osseous defects
Tissue-engineered cultured periosteum used with platelet-rich plasma and hydroxyapatite in treating human osseous defects
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DOI：
10.1902/jop.2008.070518
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发表时间：
2008-05-01
影响因子：
4.3
通讯作者：
Yoshie, Hiromasa
中科院分区：
文献类型：
--
作者：
Yamamiya, Kancko;Okuda, Kazuhiro;Yoshie, Hiromasa
背景资料：本对照临床研究的目的是比较人培养骨膜（HCP）片与富血小板血浆（PRP）和多孔羟基磷灰石（HA）颗粒组合与PRP和HA混合物治疗人骨下牙周缺损的临床反应。方法：30名健康、不吸烟、诊断为慢性牙周炎的受试者的30个邻间骨下骨缺损被纳入本研究。将受试者随机分配至试验组（HCP片联合PRP和HA）或对照组（PRP联合HA）。结果：与基线相比，12个月的结果表明，两种治疗方式导致了统计学上显著的变化（P
Background: The aim of the present controlled clinical study was to compare the clinical response of human cultured periosteum (HCP) sheets in combination with platelet-rich plasma (PRP) and porous hydroxyapatite (HA) granules to a mixture of PRP and HA in the treatment of human infrabony periodontal defects.Methods: Thirty interproximal infrabony osseous defects in 30 healthy, non-smoking subjects diagnosed with chronic periodontitis were included in this study. The subjects were randomly assigned to the test group (HCP sheets combined with PRP and HA) or the control group (PRP with HA). Clinical and radiographic measurements were made at baseline and the 12-month post-surgical evaluation.Results: Compared to baseline, the 12-month results indicated that both treatment modalities resulted in statistically significant changes (P