Urinary markers of oxidative stress respond to infection and late-life in wild chimpanzees
Urinary markers of oxidative stress respond to infection and late-life in wild chimpanzees
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DOI：
10.1371/journal.pone.0238066
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发表时间：
2020-09-11
期刊：
影响因子：
3.7
通讯作者：
Thompson, Melissa Emery
中科院分区：
文献类型：
--
作者：
Gonzalez, Nicole Thompson;Otali, Emily;Thompson, Melissa Emery
氧化应激（OS）在衰老过程中发挥着显着作用，是由各种压力源引起的，使其成为衡量健康的有力指标，也是检查与物种内部和跨物种生命史投资相关的成本的一种方法。然而，在野外条件下，特别是在灵长类动物中，很少有尿液 OS 标记物被检查过，而且它们在非侵入性监测急性应激源成本与衰老相关长期损害方面的效用还知之甚少。在这项研究中，我们在 5 种验证范例下检查了生活在乌干达基巴莱国家公园的 37 只野生黑猩猩的 5 种氧化损伤和保护尿液标记物的变化。我们使用 924 份尿液样本来检查对急性免疫挑战（呼吸道疾病或严重受伤）的反应，以及随年龄变化的混合纵向和个体内变化。 DNA 损伤 (8-OHdG) 与所有其他损伤标志物（F-异前列烷、MDA-TBARS 和新蝶呤）呈正相关，但与保护作用（总抗氧化能力）不相关。在个体中，所有损伤标记至少对一种（如果不是两种）类型的急性感染都有反应。虽然 OS 预计会随着年龄的增长而增加，但黑猩猩的情况通常并非如此。然而，在过去的壮年个体和接近死亡的个体中检测到氧化损伤的显着变化。我们的结果表明，OS 可以使用现场收集的尿液来测量，并整合健康的短期和长期方面。他们进一步表明，需要更多来自长寿野生动物的数据来阐明与年龄相关的炎症和操作系统损伤的常见增加在人类中是典型的还是最近出现的异常。
Oxidative stress (OS) plays a marked role in aging and results from a variety of stressors, making it a powerful measure of health and a way to examine costs associated with life history investments within and across species. However, few urinary OS markers have been examined under field conditions, particularly in primates, and their utility to non-invasively monitor the costs of acute stressors versus the long-term damage associated with aging is poorly understood. In this study, we examined variation in 5 urinary markers of oxidative damage and protection under 5 validation paradigms for 37 wild, chimpanzees living in the Kibale National Park, Uganda. We used 924 urine samples to examine responses to acute immune challenge (respiratory illness or severe wounding), as well as mixed-longitudinal and intra-individual variation with age. DNA damage (8-OHdG) correlated positively with all other markers of damage (F-isoprostanes, MDA-TBARS, and neopterin) but did not correlate with protection (total antioxidant capacity). Within individuals, all markers of damage responded to at least one if not both types of acute infection. While OS is expected to increase with age, this was not generally true in chimpanzees. However, significant changes in oxidative damage were detected within past-prime individuals and those close to death. Our results indicate that OS can be measured using field-collected urine and integrates short- and long-term aspects of health. They further suggest that more data are needed from long-lived, wild animals to illuminate if common age-related increases in inflammation and OS damage are typical or recently aberrant in humans.