Challenges in estimating waning effectiveness of two doses of BNT162b2 and ChAdOx1 COVID-19 vaccines beyond six months: an OpenSAFELY cohort study using linked electronic health records
Challenges in estimating waning effectiveness of two doses of BNT162b2 and ChAdOx1 COVID-19 vaccines beyond six months: an OpenSAFELY cohort study using linked electronic health records
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评估两剂 BNT162b2 和 ChAdOx1 COVID-19 疫苗六个月后有效性减弱的挑战：使用链接电子健康记录的 OpenSAFELY 队列研究
DOI：
10.1101/2023.01.04.22283762
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Horne E
中科院分区：
文献类型：
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作者：
Horne E
量化第二次COVID-19疫苗接种超过6个月和针对组粒变异的有效性减弱，对于安排后续剂量非常重要。在英国国家医疗服务体系（NHS England）的批准下，我们估计了第二次注射后一年的有效性，但发现这种估计可能存在很大的偏差。
Quantifying the waning effectiveness of second COVID-19 vaccination beyond six months and against the omicron variant is important for scheduling subsequent doses. With the approval of NHS England, we estimated effectiveness up to one year after second dose, but found that bias in such estimates may be substantial.
DOI：
10.1056/nejmoa2119451
发表时间：
2022-04-21
期刊：
The New England journal of medicine
影响因子：
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作者：
Andrews N;Stowe J;Kirsebom F;Toffa S;Rickeard T;Gallagher E;Gower C;Kall M;Groves N;O'Connell AM;Simons D;Blomquist PB;Zaidi A;Nash S;Iwani Binti Abdul Aziz N;Thelwall S;Dabrera G;Myers R;Amirthalingam G;Gharbia S;Barrett JC;Elson R;Ladhani SN;Ferguson N;Zambon M;Campbell CNJ;Brown K;Hopkins S;Chand M;Ramsay M;Lopez Bernal J
通讯作者：
Lopez Bernal J