ACTIVITY-DEPENDENT REGULATION OF CONDUCTANCES IN MODEL NEURONS
ACTIVITY-DEPENDENT REGULATION OF CONDUCTANCES IN MODEL NEURONS
复制标题
DOI：
10.1126/science.8456317
复制
发表时间：
1993-03-26
期刊：
影响因子：
56.9
通讯作者：
ABBOTT, LF
中科院分区：
文献类型：
--
作者：
LEMASSON, G;MARDER, E;ABBOTT, LF
尽管通道周转、细胞生长和细胞外条件变化，神经元仍保持其电活动模式。提出了一个模型，其中离子电流的最大电导取决于细胞内钙离子的浓度，因此，间接地取决于活性。具有活动依赖的最大电导的模型神经元在受到干扰时改变其电导以维持给定的行为。此外，由同一套方程描述的神经元可以根据不同的突触前活动模式发展出不同的特性。
Neurons maintain their electrical activity patterns despite channel turnover, cell growth, and variable extracellular conditions. A model is presented in which maximal conductances of ionic currents depend on the intracellular concentration of calcium ions and so, indirectly, on activity. Model neurons with activity-dependent maximal conductances modify their conductances to maintain a given behavior when perturbed. Moreover, neurons that are described by identical sets of equations can develop different properties in response to different patterns of presynaptic activity.