HPA and SAM axis responses as correlates of self- vs parental ratings of anxiety in boys with an Autistic Disorder
HPA and SAM axis responses as correlates of self- vs parental ratings of anxiety in boys with an Autistic Disorder
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DOI：
10.1016/j.physbeh.2013.12.011
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发表时间：
2014-03-29
影响因子：
2.9
通讯作者：
McFarlane, James R.
中科院分区：
文献类型：
--
作者：
Bitsika, Vicki;Sharpley, Christopher F.;McFarlane, James R.
焦虑和自闭症 (AD) 都是神经系统疾病，并且这两种疾病都有一些共同的特征，因此很难准确地将特定症状分配给每种疾病。 HPA 和 SAM 轴活动已确定与焦虑相关，并且可能提供一种验证患有 AD 的父母及其孩子对这些孩子进行的焦虑评级量表评估的方法。从 32 名患有自闭症 (AD) 的高功能男孩（中号 = 11 岁）样本中收集 HPA 轴（唾液皮质醇）和 SAM 轴（唾液 α 淀粉酶）反应的数据，并将其与男孩及其母亲对男孩焦虑的评分进行比较。男孩们的自我评价和他们的母亲对他们的评价之间存在显着差异。此外，只有男孩的焦虑自评能够显着预测 HPA 轴反应，而两者都与 SAM 轴反应没有显着相关。一些男孩表现出皮质醇反应，这与之前报道的因社交压力而遭受慢性和严重焦虑的儿童的皮质醇反应类似。这些数据不仅表明一些患有 AD 的男孩可以对他们的焦虑进行有效的自我评估，还表明这些男孩存在非常高水平的慢性 HPA 轴唤醒以及随之而来的慢性焦虑。 (C) 2014 Elsevier Inc. 保留所有权利。
Anxiety and Autistic Disorder (AD) are both neurological conditions and both disorders share some features that make it difficult to precisely allocate specific symptoms to each disorder. HPA and SAM axis activities have been conclusively associated with anxiety, and may provide a method of validating anxiety rating scale assessments given by parents and their children with AD about those children. Data from HPA axis (salivary cortisol) and SAM axis (salivary alpha amylase) responses were collected from a sample of 32 high-functioning boys (M age = 11 yr) with an Autistic Disorder (AD) and Were compared with the boys' and their mothers' ratings of the boys' anxiety. There was a significant difference between the self-ratings given by the boys and ratings given about them by their mothers. Further, only the boys' self-ratings of their anxiety significantly predicted the HPA axis responses and neither were significantly related to SAM axis responses. Some boys showed cortisol responses which were similar to that previously reported in children who had suffered chronic and severe anxiety arising from stressful social interactions. As well as suggesting that some boys with an AD can provide valid self-assessments of their anxiety, these data also point to the presence of very high levels of chronic HPA-axis arousal and consequent chronic anxiety in these boys. (C) 2014 Elsevier Inc. All rights reserved.