Vestibulo-ocular disturbances in rats exposed to organic solvents.
Vestibulo-ocular disturbances in rats exposed to organic solvents.
复制标题
暴露于有机溶剂的大鼠的前庭眼部紊乱。
DOI：
10.1111/j.1600-0773.1984.tb01895.x
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发表时间：
2009
期刊：
影响因子：
--
通讯作者：
L. Ödkvist
中科院分区：
文献类型：
--
作者：
R. Tham;I. Bunnfors;B. Eriksson;B. Larsby;S. Lindgren;L. Ödkvist
本文用加速旋转法记录大鼠眼球震颤，研究了不同工业溶剂对大鼠前庭功能的影响。该效应与溶剂的血液水平有关。一组溶剂，包括二氯甲烷等卤代饱和烃，会导致前庭动眼反射（VOR）抑制。另一组，包括苯化合物，如二甲苯，甲苯，苯乙烯和异丙苯和卤代不饱和烃，如三氯乙烯引起的VOR的激发。最后一组中不同溶剂之间最显著的化学相似性是双键的出现。如果动物同时暴露于两组溶剂，则兴奋效应占优势，甚至增强。有人建议，溶剂引起抑郁症或兴奋的VOR的相互作用与中央通路的网状结构和小脑。
The influence of different kinds of industrial solvents on the vestibular function of rats has been studied by recording nystagmus, induced by accelerated rotation. The effect was related to the blood levels of the solvents. One group of solvents, including halogenated saturated hydrocarbons like dichloromethane, caused depression of the vestibulo-oculomotor reflex (VOR). Another group, including benzene compounds like xylene, toluene, styrene and cumene and halogenated unsaturated hydrocarbons like trichloroethylene caused an excitation of the VOR. The most striking chemical similarity between the different solvents in the last group is the occurrence of double-bonds. If the animals were exposed simultaneously to solvents from both groups the excitatory effect prevailed and was even potentiated. It is suggested that solvents cause depression or excitation of the VOR by interaction with central pathways in the reticular formation and the cerebellum.