Effect of Modest Salt Reduction on Skin Capillary Rarefaction in White, Black, and Asian Individuals With Mild Hypertension
Effect of Modest Salt Reduction on Skin Capillary Rarefaction in White, Black, and Asian Individuals With Mild Hypertension
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DOI：
10.1161/hypertensionaha.110.155747
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发表时间：
2010-08-01
期刊：
影响因子：
8.3
通讯作者：
MacGregor, Graham A.
中科院分区：
文献类型：
--
作者：
He, Feng J.;Marciniak, Maciej;MacGregor, Graham A.
高血压时会出现微血管稀疏。我们进行了一项为期 12 周的随机双盲交叉试验，以确定适度减少盐摄入量对 71 名白人、69 名黑人和 29 名未经治疗的轻度高血压的亚洲人毛细血管稀疏的影响。通过毛细血管镜在手指的背部和侧面测量基础和最大（静脉充血期间）皮肤毛细血管密度。此外，我们使用正交偏振光谱成像来测量手指背和手蹼处的皮肤毛细血管密度。随着盐摄入量从 9.7 克/天减少到 6.5 克/天，毛细血管密度（每平方毫米毛细血管）从 101 +/- 21 增加到 106 +/- 23（基础），背部从 108 +/- 22 增加到 115 +/- 22（最大），背部从 101 +/- 25 增加到 107 +/- 26（基础），手指侧面 110 +/- 26 至 116 +/- 26（最大）（P
Microvascular rarefaction occurs in hypertension. We carried out a 12-week randomized double-blind crossover trial to determine the effect of a modest reduction in salt intake on capillary rarefaction in 71 whites, 69 blacks, and 29 Asians with untreated mildly raised blood pressure. Both basal and maximal (during venous congestion) skin capillary density were measured by capillaroscopy at the dorsum and the side of the fingers. In addition, we used orthogonal polarization spectral imaging to measure skin capillary density at the dorsum of the fingers and the hand web. With a reduction in salt intake from 9.7 to 6.5 g/day, there was an increase in capillary density (capillaries per millimeter squared) from 101 +/- 21 to 106 +/- 23 (basal) and 108 +/- 22 to 115 +/- 22 (maximal) at the dorsum, and 101 +/- 25 to 107 +/- 26 (basal) and 110 +/- 26 to 116 +/- 26 (maximal) at the side of the fingers (P