Peripheral Mechanisms of Remote Ischemic Conditioning.
Peripheral Mechanisms of Remote Ischemic Conditioning.
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发表时间：
2019-02
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通讯作者：
Jiwon Yang;Faariah Shakil;Sunghee Cho
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作者：
Jiwon Yang;Faariah Shakil;Sunghee Cho
缺血条件诱导内源性保护机制，使生物体发展抵抗随后的侮辱。条件作用发生在器官和物种之间。近年来，由于其无创性和潜在的治疗应用，远程缺血肢体预处理受到了广泛关注。虽然耐受性是在原发性损伤部位诱导的（例如，心脏缺血时的心脏和中风时的大脑），但条件作用的部位远离靶器官，这表明保护因素是外在的而不是内在的。这篇综述将集中于解释耐受诱导的外周因素。特别感兴趣的主题是血流变化，外周神经通路，循环中的体液因子和外周免疫系统。这篇综述还将讨论条件反射如何对代谢受损的情况产生负面影响，其最佳剂量和治疗开发的窗口。
Ischemic conditioning induces an endogenous protective mechanism that allows organisms to develop resistance to subsequent insults. The conditioning effect occurs across organs and species. Recently, much attention has been given to remote ischemic limb conditioning due to its non-invasive nature and potential therapeutic applications. While tolerance is induced at the primary injury site (e.g. the heart in cardiac ischemia and the brain in stroke), the site of conditioning application is away from the target organ, suggesting the protective factors are extrinsic in nature rather than intrinsic. This review will focus on the peripheral factors that account for the induction of tolerance. Topics of particular interest are blood flow changes, peripheral neural pathways, humoral factors in circulation, and the peripheral immune system. This review will also discuss how conditioning may negatively affect metabolically compromised conditions, its optimal dose, and window for therapy development.