Computer-aided neurocognitive remediation as an enhancing strategy for schizophrenia rehabilitation
Computer-aided neurocognitive remediation as an enhancing strategy for schizophrenia rehabilitation
复制标题
DOI：
10.1016/j.psychres.2008.06.027
复制
发表时间：
2009-10-30
影响因子：
11.3
通讯作者：
Smeraldi, Enrico
中科院分区：
文献类型：
--
作者：
Cavallaro, Roberto;Anselmetti, Simona;Smeraldi, Enrico
认知功能障碍是精神分裂症的慢性致残特征，与获得康复改善的限制有关。本研究的目的是评估强化计算机辅助认知修复治疗（CRT）在标准康复治疗（SRT）的基础上增强精神分裂症患者神经心理表现和日常功能的有效性。12周。对86例临床稳定的DSM-IV型精神分裂症患者进行神经认知修复的随机、对照、单盲试验。在CRT或安慰剂训练加入SRT之前和之后，对患者的认知和日常功能进行评估。3个月后，重复测量方差分析显示，SRT + CRT治疗的患者在执行功能和注意力表现以及日常功能评估方面具有显著的时间x治疗相互作用。结果证实，在精神分裂症的SRT中添加认知修复可以增强其神经心理效果，并在功能结果方面增加长期康复计划的效果。2008爱思唯尔爱尔兰有限公司版权所有。
Cognitive dysfunction is a chronically disabling feature of schizophrenia, associated with limits in obtaining rehabilitation improvements. The purpose of this study is to assess the effectiveness of intensive computer-aided cognitive remediation treatment (CRT) added to a standard rehabilitation treatment (SRT), in enhancing neuropsychological performances and daily functioning in patients with schizophrenia. A 12-week. randomized, controlled, single-blind trial of neurocognitive remediation was carried out on 86 patients with clinically stabilized DSM-IV schizophrenia. Patients were assessed on cognitive and daily functioning before and after either CRT or placebo training that had been added to their SRT. After 3 months the repeated measure ANOVA showed a significant time x treatment interaction for executive function and attention performances and in daily functioning assessment in favour of patients in the SRT + CRT treatment. Results confirmed that cognitive remediation added to the SRT of schizophrenia enhanced its neuropsychological effects and increased the effects of a long-term rehabilitation programme in terms of functional outcomes. (C) 2008 Elsevier Ireland Ltd. All rights reserved.